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Time for radioimmunotherapy: an overview to bring improvements in clinical practice

  • O. Leaman AlcibarEmail author
  • D. Candini
  • F. López-Campos
  • M. Albert Antequera
  • V. Morillo Macías
  • A. J. Conde
  • A. Rodríguez Pérez
  • A. Hervás Morón
  • J. Contreras Martínez
  • C. Ferrer Albiach
  • S. Navarro Aguilar
  • M. E. Rodríguez-Ruiz
Review Article
  • 219 Downloads

Abstract

Harnessing the patient’s own immune system against an established cancer has proven to be a successful strategy. Within the last years, several antibodies blocking critical “checkpoints” that control the activation of T cells, the immune cells able to kill cancer cells, have been approved for the use in patients with different tumours. Unfortunately, these cases remain a minority. Over the last years, radiotherapy has been reported as a means to turn a patient’s own tumour into an in situ vaccine and generate anti-tumour T cells in patients who lack sufficient anti-tumour immunity. Indeed, review data show that the strategy of blocking multiple selected immune inhibitory targets in combination with radiotherapy has the potential to unleash powerful anti-tumour responses and improve the outcome of metastatic solid tumours. Here, we review the principal tumours where research in this field has led to new knowledge and where radioimmunotherapy becomes a reality.

Keywords

Abscopal effect Radiotherapy Radioimmunotherapy Immunotherapy combinations Immunogenic neoplasms 

Notes

Compliance with ethical standards

Conflict of interest

No potential conflicts of interest were disclosed.

Ethical approval

This review article did not imply research involving humans or animals.

Informed consent

Informed consent was not required.

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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2019

Authors and Affiliations

  • O. Leaman Alcibar
    • 1
    Email author
  • D. Candini
    • 2
  • F. López-Campos
    • 2
  • M. Albert Antequera
    • 3
  • V. Morillo Macías
    • 4
  • A. J. Conde
    • 5
  • A. Rodríguez Pérez
    • 6
  • A. Hervás Morón
    • 2
  • J. Contreras Martínez
    • 7
  • C. Ferrer Albiach
    • 4
  • S. Navarro Aguilar
    • 8
  • M. E. Rodríguez-Ruiz
    • 9
  1. 1.Radiation Oncology DepartmentCentral University Hospital of Defence Gómez UllaMadridSpain
  2. 2.Radiation Oncology DepartmentRamón y Cajal University HospitalMadridSpain
  3. 3.Radiation Oncology DepartmentLa Ribera University HospitalValenciaSpain
  4. 4.Radiation Oncology DepartmentGeneral Hospital in Castellón de la PlanaCastellónSpain
  5. 5.Radiation Oncology DepartmentThe University and Polytechnic La Fe HospitalValenciaSpain
  6. 6.Radiation Oncology DepartmentInternacional Ruber HospitalMadridSpain
  7. 7.Radiation Oncology DepartmentMálaga HospitalMálagaSpain
  8. 8.Radiation Oncology Department, Oncology and Radiotherapy InstitutRicardo Palma ClinicLimaPeru
  9. 9.Radiation Oncology DepartmentUniversity of Navarra Clinic and CIMANavarraSpain

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