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Indian Journal of Microbiology

, Volume 59, Issue 4, pp 417–421 | Cite as

Antiherpetic Effect of Topical Formulations Containing Sulfated Polysaccharide from Adenanthera pavonina

  • Daniele Zendrini Rechenchoski
  • Karoline Fontana Agostinho
  • Ligia Carla Faccin-Galhardi
  • Audrey Alesandra Stinghen Garcia Lonni
  • Arcelina Pacheco Cunha
  • Nágila Maria Pontes Silva Ricardo
  • Carlos Nozawa
  • Rosa Elisa Carvalho LinharesEmail author
Original research article
  • 76 Downloads

Abstract

Adenanthera pavonina is a native tree of Africa and Asia, introduced in Brazil for reforestation and wood industry. Several pharmacological activities have described scientifically, including antiviral activity. This study evaluated the antiviral effect of sulfated polysaccharide of Adenanthera pavonina (SPAp) against acyclovir (ACV)—resistant (AR-29) and sensitive (KOS) herpes simplex virus strains. The 50% cytotoxic concentration (CC50) was determined by MTT method and the 50% inhibitory concentration (IC50) was evaluated by plaque reduction assay. The in vivo SPAp antiviral activity was performed in Balb/c mice infected by skin scarification and treated with topical 0.5% (w/w) SPAp formulations. SPAp showed a CC50 of 47.81 μg/mL and the IC50 were 0.49 μg/mL (SI = 97.5) and 0.54 μg/mL (SI = 88.5) for the strains KOS and AR-29, respectively. Our results demonstrated that mice treated with SPAp presented a delay in the development and progression of skin lesions compared with the control group.

Keywords

Adenanthera pavonina Antiviral Fabaceae Herpes simplex virus Polysaccharide 

Notes

Acknowledgements

The authors thank to CAPES (finance code 001), CNPq, Fundação Araucaria and UEL for financial support.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Association of Microbiologists of India 2019

Authors and Affiliations

  • Daniele Zendrini Rechenchoski
    • 1
    • 2
  • Karoline Fontana Agostinho
    • 1
  • Ligia Carla Faccin-Galhardi
    • 1
  • Audrey Alesandra Stinghen Garcia Lonni
    • 2
  • Arcelina Pacheco Cunha
    • 3
  • Nágila Maria Pontes Silva Ricardo
    • 3
  • Carlos Nozawa
    • 1
  • Rosa Elisa Carvalho Linhares
    • 1
    Email author
  1. 1.Departamento de Microbiologia/CCBUniversidade Estadual de LondrinaLondrinaBrazil
  2. 2.Departamento de Ciências FarmacêuticasUniversidade Estadual de LondrinaLondrinaBrazil
  3. 3.Departamento de Química Orgânica e InorgânicaUniversidade Federal do CearáFortalezaBrazil

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