Indian Journal of Microbiology

, Volume 59, Issue 2, pp 241–245 | Cite as

Changes in Gene Expression in Human Epithelial and Mast Cells in Response to Vesicles from Klebsiella pneumonia ATCC 13883

  • Hee Sang You
  • Yeon Jeong Ok
  • Song Hee Lee
  • Sang Sun Kang
  • Sung Hee HyunEmail author
Short Communications


We investigated alterations in the expression of immune-related genes in epithelial cells and mast cells treated with outer membrane vesicles (OMVs) derived from Klebsiella pneumoniae (KpOMVs). Previous studies have shown that OMVs contain substances that enable their delivery to host cells and induce an immune response. Our results indicate an increase in expression of genes such as IL-8, IL-1b, MIP-, HMOX1, HSPA1A, and IL-24 in epithelial cells and mast cells treated with KpOMVs. The pathogenicity of KpOMVs was confirmed by measuring the changes in the expression of these immune-related genes.


Klebsiella pneumoniae Immune related genes Outer membrane vesicles Pathogen Toxin 



This research was supported by the Basic Science Research Program, through the National Research Foundation of Korea (NRF), funded by the Ministry of Science ICT & Future Planning (NRF-2014R1A1A1002349).

Compliance with Ethical Standards

Conflict of interest

The authors have no conflict of interest (commercial or otherwise) to declare regarding this study.


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Copyright information

© Association of Microbiologists of India 2018

Authors and Affiliations

  1. 1.Department of Biomedical Laboratory Science, School of MedicineEulji UniversityDaejeonRepublic of Korea
  2. 2.BK21 Plus Program, Department of Senior Healthcare, Graduate SchoolEulji UniversityDaejeonRepublic of Korea
  3. 3.School of Science EducationChungbuk National UniversityChongjuRepublic of Korea

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