Journal of Cell Communication and Signaling

, Volume 13, Issue 3, pp 277–278 | Cite as

Do drugs that target mTOR generate CCN2-mediated fibrogenic side effects?

  • Andrew LeaskEmail author


mTOR, the target of rapamycin, has been promoted as a potential target for cancers, transplantations and even lung fibrosis. However, paradoxically, targeting mTOR has been reported to result in profibrotic side effects. Some recent publications highlight why this might be.


CCN2 CCN3 CCN1 mTOR Rapamycin Everolimus Fibrosis 



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Copyright information

© The International CCN Society 2019

Authors and Affiliations

  1. 1.Department of DentistryWestern UniversityLondonCanada

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