Journal of Cell Communication and Signaling

, Volume 13, Issue 3, pp 291–301 | Cite as

The endothelial tip-stalk cell selection and shuffling during angiogenesis

  • Wenqi Chen
  • Peng Xia
  • Heping Wang
  • Jihao Tu
  • Xinyue Liang
  • Xiaoling ZhangEmail author
  • Lisha LiEmail author


Angiogenesis is a critical, fine-tuned, multi-staged biological process. Tip-stalk cell selection and shuffling are the building blocks of sprouting angiogenesis. Accumulated evidences show that tip-stalk cell selection and shuffling are regulated by a variety of physical, chemical and biological factors, especially the interaction among multiple genes, their products and environments. The classic Notch-VEGFR, Slit-Robo, ECM-binding integrin, semaphorin and CCN family play important roles in tip-stalk cell selection and shuffling. In this review, we outline the progress and prospect in the mechanism and the roles of the various molecules and related signaling pathways in endothelial tip-stalk cell selection and shuffling. In the future, the regulators of tip-stalk cell selection and shuffling would be the potential markers and targets for angiogenesis.


Angiogenesis Endothelial cells Tip-stalk cell selection Tip-stalk shuffling Signaling pathway 



This study was funded by the National Natural Science Foundation of China (Grant No. 31201052, 81802815). We thank Man Lu and Huiyu Li for polishing the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© The International CCN Society 2019

Authors and Affiliations

  1. 1.The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical SciencesJilin UniversityChangchunChina
  2. 2.Department of AnesthesiaJilin Provincial People′s HospitalChangchunChina
  3. 3.Department of Neurosurgery, Tongji Hospital, Tongji Medical SchoolHuazhong University of Science and TechnologyWuhanChina
  4. 4.The First Hospital of Jilin UniversityChangchunChina
  5. 5.Institute of ImmunologyJilin UniversityChangchunChina

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