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Hepatology International

, Volume 13, Issue 5, pp 546–559 | Cite as

Radiomics in hepatocellular carcinoma: a quantitative review

  • Taiga Wakabayashi
  • Farid Ouhmich
  • Cristians Gonzalez-Cabrera
  • Emanuele Felli
  • Antonio Saviano
  • Vincent Agnus
  • Peter Savadjiev
  • Thomas F. Baumert
  • Patrick Pessaux
  • Jacques Marescaux
  • Benoit GallixEmail author
Review Article

Abstract

Radiomics is an emerging field which extracts quantitative radiology data from medical images and explores their correlation with clinical outcomes in a non-invasive manner. This review aims to assess whether radiomics is a useful and reproducible method for clinical management of hepatocellular carcinoma (HCC) by reviewing the strengths and weaknesses of current radiomics literature pertaining specifically to HCC. From an initial set of 48 articles recovered through database searches, 23 articles were retained to be included in this review after full screening. Among these 23 studies, 7 used a radiomics approach in magnetic resonance imaging (MRI). Only two studies applied radiomics to positron emission tomography–computed tomography (PET–CT). In the remaining 14 articles, a radiomics analysis was performed on computed tomography (CT). Eight studies dealt with the relationship between biological signatures and imaging findings, and can be classified as radiogenomic studies. For each study included in our review, we computed a Radiomics Quality Score (RQS) as proposed by Lambin et al. We found that the RQS (mean ± standard deviation) was 8.35 ± 5.38 (out of a possible maximum value of 36). Although these scores are fairly low, and radiomics has not yet reached clinical utility in HCC, it is important to underscore the fact that these early studies pave the way for the radiomics field with a focus on HCC. Radiomics is still a very young field, and is far from being mature, but it remains a very promising technology for the future for developing adequate personalized treatment as a non-invasive approach, for complementing or replacing tumor biopsies, as well as for developing novel prognostic biomarkers in HCC patients.

Keywords

Radiomics Radiogenomics Hepatocellular carcinoma Tumor heterogeneity 

Notes

Acknowledgements

The authors acknowledge the support of ARC, Paris and Institut hospitalo-universitaire, Strasbourg (TheraHCC IHUARC IHU201301187), as well as the European Union (ERC-AdG-2014-671,231-HEPCIR, H2020-667273-HEPCAR). In addition, the authors are grateful to Camille Goustiaux, Christopher Burel, and Guy Temporal for their assistance in proofreading the manuscript.

Author contributions

TW and BG designed the research; TW and FO extracted the data; TW, PS and BG wrote the paper; CG, EF, AS, VA, TFB, PP, and BG edited the paper; JM supervised the paper; All authors read and approved the final manuscript.

Compliance with ethical standards

Conflict of interest

Thomas F. Baumert, Patrick Pessaux, Jacques Marescaux, and Benoit Gallix have received research grants from ARC, Paris and Institut hospitalo-universitaire, Strasbourg (TheraHCC IHUARC IHU201301187). Antonio Saviano and Thomas F. Baumert have received research grants from the European Union (ERC-AdG-2014-671231-HEPCIR, H2020-667273-HEPCAR). Taiga Wakabayashi, Farid Ouhmich, Cristians Gonzalez-Cabrera, Emanuele Felli, Vincent Agnus, and Peter Savadjiev declare that they have no conflict of interest.

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Copyright information

© Asian Pacific Association for the Study of the Liver 2019

Authors and Affiliations

  • Taiga Wakabayashi
    • 1
  • Farid Ouhmich
    • 2
  • Cristians Gonzalez-Cabrera
    • 2
  • Emanuele Felli
    • 1
    • 2
    • 3
    • 4
    • 5
  • Antonio Saviano
    • 2
    • 4
    • 5
  • Vincent Agnus
    • 2
  • Peter Savadjiev
    • 6
  • Thomas F. Baumert
    • 2
    • 4
    • 5
  • Patrick Pessaux
    • 1
    • 2
    • 3
    • 4
    • 5
  • Jacques Marescaux
    • 1
    • 2
    • 3
  • Benoit Gallix
    • 2
    • 6
    Email author
  1. 1.Institut de Recherche Contre les Cancers de l’Appareil Digestif (IRCAD)StrasbourgFrance
  2. 2.Institut hospitalo-universitaire (IHU), Institute for Minimally Invasive Hybrid Image-Guided Surgery, Université de StrasbourgStrasbourgFrance
  3. 3.General, Digestive, and Endocrine Surgery, Nouvel Hôpital Civil, Université de StrasbourgStrasbourgFrance
  4. 4.Inserm, U1110Institut de Recherche sur les Maladies Virales et Hépatiques, Université de StrasbourgStrasbourgFrance
  5. 5.Pôle Hépato-digestif, Hôpitaux UniversitairesStrasbourgFrance
  6. 6.Department of Diagnostic RadiologyMcGill UniversityMontrealCanada

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