Hepatology International

, Volume 13, Issue 5, pp 534–545 | Cite as

Reversal of NASH fibrosis with pharmacotherapy

  • Joseph J. Alukal
  • Paul J. ThuluvathEmail author
Review Article


NAFLD is a spectrum of liver disease starting with fatty liver at one end of the spectrum and cirrhosis or liver cancer at the other end. Worldwide, NAFLD has become one of the most common liver diseases and it has also become one of the leading indications for liver transplantation. Our understanding of the NAFLD epidemiology, pathogenesis and its progression to cirrhosis has improved over the last 2 decades. Currently, however, there are no FDA-approved treatment options for fibrosis resulting from NAFLD. A number of compounds targeting multiple pathways involved in the progression of NAFLD are currently in phase 2–3 trials. In this review, we will briefly discuss the epidemiology, the pathogenesis and the current status of treatment of NAFLD.


NAFLD NASH Antifibrotic agents 


Author contributions

JJA and PJT contributed to the drafting of the article or critical revision of important intellectual content.



Compliance with ethical standards

Conflict of interest

Joseph J. Alukal and Paul J. Thuluvath declare that they have no competing interests.


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Copyright information

© Asian Pacific Association for the Study of the Liver 2019

Authors and Affiliations

  1. 1.Institute of Digestive Health and Liver DiseasesMercy Medical CenterBaltimoreUSA
  2. 2.Department of MedicineUniversity of Maryland School of MedicineBaltimoreUSA

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