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Ascitic fluid infection in children with liver disease: time to change empirical antibiotic policy

  • Sumit Kumar Singh
  • Ujjal PoddarEmail author
  • Richa Mishra
  • Anshu Srivastava
  • Surender Kumar Yachha
Original Article

Abstract

Background and aims

Recent years have shown a rise in occurrence of multidrug resistant ascitic fluid infection (AFI) including resistant to third generation cephalosporins. Our aim was to find the prevalence, antibiotics resistance and outcome of AFI in children with liver disease.

Methods

Children (≤ 18 years) with liver disease-related ascites were prospectively enrolled from April 2015 to October 2017. Based on the results of ascitic fluid examination and culture, patients were classified as having AFI [spontaneous bacterial peritonitis (SBP), culture negative neutrocytic ascites (CNNA) and monomicrobial non-neutrocytic bacterascites (MNB)] and no-AFI. AFI diagnosed after 48 h of index hospitalization was considered as nosocomial.

Results

We enrolled 194 children with a median age of 85 [2–216] months. Chronic liver disease was the commonest etiology (153, 79%). AFI was present in 60 (31%) children [SBP (n = 13), CNNA (n = 39), MNB (n = 8)] of which 53% were nosocomial and resulted in high in-hospital mortality. Gram-negative bacilli dominated the ascitic fluid culture (12/21, 57%) and 10/12 (83%) of them were extended spectrum beta-lactamases (ESBL) producers. Six (60%) ESBL producers were sensitive to cefoperazone–sulbactam and 70% to carbapenems. Child–Pugh-Turcotte (CPT) score of ≥ 11 independently determined in-hospital mortality in children with AFI.

Conclusions

AFI was found in 31% children with liver disease and almost half of them were nosocomial resulting in high mortality. ESBL producing Gram-negative bacteria were the most frequently isolated organisms. Cefoperazone–sulbactam or carbapenems may be useful empirical antibiotics in nosocomial setting. Children with AFI and CPT score ≥ 11 should be evaluated for liver transplantation.

Keywords

Ascites Children Nosocomial Infection 

Notes

Compliance with ethical standards

Conflict of interest

Sumit Kumar Singh, Ujjal Poddar, Richa Mishra, Anshu Srivastava and Surender Kumar Yachha declare that they have no conflict of interest.

Ethical standard

The primary study was approved by the institutional ethics committee, Sanjay Gandhi Postgraduate Institute of Medical Sciences and conducted in compliance with the Good Clinical Practice guidelines, the Declaration of Helsinki, and regulatory requirements.

Informed consent

All patients provided written informed consent and all protocols were approved by the institutional ethics committee.

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Copyright information

© Asian Pacific Association for the Study of the Liver 2019

Authors and Affiliations

  1. 1.Department of Pediatric GastroenterologySanjay Gandhi Postgraduate Institute of Medical SciencesLucknowIndia
  2. 2.Department of MicrobiologySanjay Gandhi Postgraduate Institute of Medical SciencesLucknowIndia

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