Hepatology International

, Volume 13, Issue 4, pp 391–394 | Cite as

New treatment-induced adverse effects we need to learn as modern hepatologists

  • Yoshiyuki UenoEmail author
Invited Commentary

In this issue, Nishida and Kudo have written a review article entitled, “Liver damage related to immune check point inhibitors.” [1]. As we know, any medical treatment, whether medical or surgical, can exert an adverse effect at any level. Classically, for example, in the field of hepatology, it is well known that microvesicular steatosis is related to the administration of aspirin, resulting in so-called Rye’s syndrome, of which the essential pathogenesis is mitochondria damage in the hepatocytes. In the age of interferon, the hypothyroidism induced by interferon administration is a well-known iatrogenic disease that frequently needs medical treatment. Moreover, even liver transplantation is consistently required for drug-induced acute liver failure worldwide. Most recently, molecular targeting drugs also induce varieties of hepatic injury while treating hepatocellular carcinoma (HCC) [2, 3]. Thus, sometimes it is ironical that we may induce new diseases during treatment in patients...


Immune check point inhibitor Liver toxicity Molecular targetting drug PD-1 PD-L1 



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Copyright information

© Asian Pacific Association for the Study of the Liver 2019

Authors and Affiliations

  1. 1.Department of GastroenterologyFaculty of Medicine Yamagata UniversityYamagataJapan

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