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Immunological cure of HBV infection

  • Julia Lang
  • Christoph Neumann-Haefelin
  • Robert ThimmeEmail author
Review Article

Abstract

Chronic hepatitis B virus (HBV) infection is a major global health burden and cure is rarely achieved by current antiviral therapies. Therefore, there is an urgent need for new therapeutic options. Immune modulation with the goal to restore dysfunctional HBV-specific immunity is an interesting target for new therapeutic strategies. Based on the current evidence on immunology in resolving and persistent HBV infection, we will review the growing field of immunotherapeutic approaches for treatment of chronic HBV infection. We will also discuss the challenge of a heterogeneous patient population and personalized treatment as a possible key factor of success.

Graphical abstract

Keywords

Adaptive immunity CD4+ T-lymphocytes CD8+ T-lymphocytes Hepatitis B Immunotherapy 

Notes

Compliance with ethical standards

Compliance with ethical requirements

This article does not contain any studies with human or animal subjects.

Conflict of interest

Julia Lang, Christoph Neumann-Haefelin and Robert Thimme declare that they have no competing interests.

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Copyright information

© Asian Pacific Association for the Study of the Liver 2019

Authors and Affiliations

  • Julia Lang
    • 1
  • Christoph Neumann-Haefelin
    • 1
  • Robert Thimme
    • 1
    Email author
  1. 1.Department of Medicine IIUniversity Hospital Freiburg, Faculty of MedicineFreiburgGermany

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