Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

A Comparative Study in the Management of Chronic Rhinosinusitis by Nasal Douching with Hypertonic Saline vs Isotonic Saline

  • 11 Accesses


Chronic rhinosinusitis is one of the most commonly diagnosed medical conditions affecting all age groups. Hypertonic saline solution and isotonic saline solution are used in management of chronic rhinosinusitis. In this study we compare the effectiveness of isotonic saline and hypertonic saline in alleviation of symptoms and clinical outcome of patients with chronic rhinosinusitis. In our study 60 patients diagnosed with chronic rhinosinusitis are divided into two groups; Group A treated with isotonic saline and Group B with 3.5% hypertonic saline for a period of 6 weeks. The symptoms were evaluated using SNOT-20 score before and after treatment. It was found that hypertonic saline solution is more efficacious than isotonic saline solution in the treatment of patients with chronic rhinosinusitis.

This is a preview of subscription content, log in to check access.

Fig. 1
Fig. 2


  1. 1.

    Wingrave W (1902) The nature of discharges and douches. The Lancet 17:1373–1375

  2. 2.

    Grossan M (1974) Irrigation of the child’s nose. Clin Pediat 13(3):229–231

  3. 3.

    Robert S (1992) Zeiger Prospects for ancillary treatment of sinusitis in the 1990s. J Allergy Clin Immunol 90:478–495

  4. 4.

    Shoseyov David, Bibi Haim, Shai Pintov, Shoseyov Nurit, Shazberg Gila, Hurvitz Haggit (1998) Treatment with hypertonic saline versus normal saline nasal wash of paediatric chronic sinusitis. J Allergy Clin lmmunol 101:602–605

  5. 5.

    Instruction Manual and General formation on Yogic Saline Nasal Cleansing Technique. The Jala-neti Booklet [cited 2005 Dec 30): (41screens). http://www.yoasanas/jala.pdf

  6. 6.

    Band BC, Mukherjee AL, Bang FB (1967) Human nasal mucous flow rates. Johns Hopkins Med J 121:38–48

  7. 7.

    Grossan M (1976) A device for nasal irrigation. ANL 3:65–70

  8. 8.

    Majima Y, Sakakura Y, Matsubara T, Murai S, Miyoshi Y (1983) Mucociliary clearance in chronic sinusitis: related huma nasal clearance and in vitro bullfrog palate clearance. Biorheology 20(25):1–62

  9. 9.

    Dulfano MJ, Adler K, Wooten O (1973) Primary properties of sputum. IV. Effects of 100 percent humidity and water mist. Am Rev Respir Dis 107:130–132

  10. 10.

    Rossman CCM, Lee RMKW, Forrest JB, Newhouse MT (1984) Nasal ciliary ultrastructure and function in patients with primary ciliary dyskinesia with that in normal subjects and in subjects with various respiratory diseases. Am Rev Respir Dis 129:161–170

  11. 11.

    Johnson NT, Villalon M, Royce FH, Hard R, Verdugo (1991) Autoregulation of beat frequency in respiratory ciliated cells. Demonstrated by viscous loading. Am Rev Respir Dis 144:1091–1094

  12. 12.

    Hirata K (1985) Dynamic viscoelasticity of nasal mucus from children with chronic sinusitis. Mic Med J 3(34):205–219

  13. 13.

    Mangete EDO, David W, Blankson CD (1992) Hypertonic saline solution for wound dressing. The Lancet 28(340):1351

  14. 14.

    Manning SC (1993) Pediatric sinusitis. Otolaryngol Clin North Am 26(4):623–638

  15. 15.

    Folkesson Hans G, Kheradmand Farrah, Matthay Michael A (1994) The effect of salt water on alveolar epithelial barrier function. Am J Rcspir Crit Care Med 150:1555–1563

  16. 16.

    Georgitis JW (1994) Nasal hyperthermia and simple irrigation for perennial rhinitis. Changes in inflammatory mediators. Chest 106:1487–1492

  17. 17.

    Daviskas E, Anderson SD, Gonda I, Eberl S, Meikle S, Seale JP et al (1996) Inhalation of hypertonic saline aerosol enhances mucociliary clearance in asthmatic and healthy subjects. Eur Respir J 9(4):725–732

Download references

Author information

Correspondence to K. Muthubabu.

Ethics declarations

Conflict of interest

There is no conflict of interest and no funding was provided.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Muthubabu, K., Srinivasan, M.K., Alagammai, S. et al. A Comparative Study in the Management of Chronic Rhinosinusitis by Nasal Douching with Hypertonic Saline vs Isotonic Saline. Indian J Otolaryngol Head Neck Surg (2020).

Download citation


  • Chronic rhinosinusitis
  • Nasal douching
  • SNOT-20 score
  • Hypertonic saline solution
  • Isotonic saline solution