Assessment of Oxidative Stress in Patients with Sudden Hearing Loss: A Non-randomized Prospective Clinical Study

  • Kadir OzdamarEmail author
  • Alper Sen
  • Ataman Gonel
Original Article


The etiology of sudden hearing loss (SHL) has not been fully elucidated. Previous studies claimed that different etiological factors may play a role in the pathogenesis of SHL. The aim of the present study is to investigate the presence of oxidative stress (OS) in SHL cases using thiol-disulfide balance. In addition, total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and lipid hydroperoxide levels (LOOH) were investigated. A total of 30 cases (15 female, 15 male, mean age 48.9 ± 8.1 years, age range: 36–68 years) were included in the study. Thiol and disulfide amounts, thiol/disulfide ratios, TOS, TAS, OSI and LOOH scores of the case group and control group were compared. Native thiol (SH) and total thiol (SH + SH) values were significantly lower in the SHL group than in the control group (p = 0.028 and p = 0.044, respectively). The LOOH value, TOS value and OSI value were significantly higher in the SHL group than in the control group (all p values < 0.05). The TAS value was significantly lower in the SHL group than in the control group (p = 0.0001). The present study has presented that the thiol-disulfide balance was impaired in SHL cases. OS may play a role in the development of SHL.


Oxidative stress Sudden hearing loss Etiology Thiol-disulfide balance 


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Association of Otolaryngologists of India 2019

Authors and Affiliations

  1. 1.Medical Faculty, Department of Otorhinolaryngology - Head and Neck SurgeryHarran UniversityŞanlıurfaTurkey
  2. 2.Medical Faculty, Department of BiochemistryHarran UniversityŞanlıurfaTurkey
  3. 3.Harran Tıp Fakültesi Araştırma ve Uygulama HastanesiŞanlıurfaTurkey

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