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A Survival Analysis of Hypopharyngeal Cancer Patients: A Hospital-Cancer registry Based Study

  • Manigreeva KrishnatreyaEmail author
  • Amal Chandra Kataki
  • Jagannath Dev Sharma
  • Nizara Baishya
  • Tashnin Rahman
  • Mouchumee Bhattcharyya
  • Ashok Kumar Das
  • Manoj Kalita
Original Article
  • 2 Downloads

Abstract

To study the survival in patients affected with hypopharyngeal cancer among treatment groups and different stages. Data of hypopharyngeal cancer patients diagnosed from 1st January 2010 to 31st December 2010 was used in the present study. The cases were analyzed for gender, age group distribution, sub-sites at presentation, stage at diagnosis and the type of treatments. Survival from the date of first diagnosis was estimated and hazard ratios were calculated. Survival probability and hazards ratios (HR) were calculated by Kaplan–Meier method and Cox-proportional regression analysis respectively. Censoring of patient who survived longer than 5 years was done. Active follow-up was done for the survival analysis. The study cohort included 217 patients and treatment compliance was observed in 46.9% of cases. The median age at diagnosis was 57 years (range 24–90), 86.2% of cases were locally advanced cases (stage III and IV), pyriform sinus was major sub-site (96%), radiotherapy was main treatment modality alone in 84.8% of cases, median survival was 31 months and 5-year overall survival was 36.9%, and HR for stage IV was 1.9 (P = 0.03, 95% CI − 1.04 to 3.7). In developing setting of North East India, radiotherapy was the main modality of treatment for hypopharyngeal cancer patients, and understanding the clinical parameters and survival of this group of cancers is crucial for its control.

Keywords

Chemotherapy Hypopharynx Radiotherapy Survival 

Notes

Acknowledgements

The authors would like to thank the National Centre for Disease Informatics and Research under Indian Council of Medical Research for providing the necessary technical support to our hospital cancer registry.

Compliance with Ethical Standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants performed by any of the authors.

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Copyright information

© Association of Otolaryngologists of India 2018

Authors and Affiliations

  • Manigreeva Krishnatreya
    • 1
    Email author
  • Amal Chandra Kataki
    • 1
    • 2
  • Jagannath Dev Sharma
    • 3
    • 4
  • Nizara Baishya
    • 4
  • Tashnin Rahman
    • 5
  • Mouchumee Bhattcharyya
    • 6
  • Ashok Kumar Das
    • 5
  • Manoj Kalita
    • 7
  1. 1.Department of Cancer Epidemiology and BiostatisticsDr B. Borooah Cancer InstituteGuwahatiIndia
  2. 2.Patterns of Care and Survival ProjectDr B. Borooah Cancer InstituteGuwahatiIndia
  3. 3.Department of PathologyDr B. Borooah Cancer InstituteGuwahatiIndia
  4. 4.Hospital Based Cancer Registry -National Cancer Registry ProgrammeDr B. Borooah Cancer InstituteGuwahatiIndia
  5. 5.Department of Head and Neck OncologyDr B. Borooah Cancer InstituteGuwahatiIndia
  6. 6.Department of Radiation OncologyDr B. Borooah Cancer InstituteGuwahatiIndia
  7. 7.Population Based Cancer Registry -National Cancer Registry ProgrammeDr B. Borooah Cancer InstituteGuwahatiIndia

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