Intracell Heat Shock Protein 70 Expression and Nasopharyngeal Carcinoma Stage

  • Elida Mustikaningtyas
  • Sri Herawati JuniatiEmail author
  • A. C. Romdhoni
Original Article


Tumor growth and metastasis in nasopharyngeal carcinoma (NPC) patients recent research stated that intracellular Hsp70 is a stress protein as the main factor for the growth, invasion and metastasis of NPC. To analyze intracellular Hsp70 protein expression of NPC patients which correlate with staging of NPC as clinical manifestation. Formalin-fixed paraffin-embedded biopsy specimens from 20 NPCs histopathology and clinically. The expression of intracellular Hsp70 was obtained using monoclonal antibody of Anti Human Hsp70 from Santa Cruz Biotechnology, California, USA. The assessment of the staining was performed with Remmele methode by Histopathologies doctor Consultant. 20 NPC patients met the inclusion and exclusion criteria. The data showed a negative intracellular of Hsp70 expression by 15% for all sample that consist of 1 patient of stage I, II, III, and none for stage IV. Then, followed by 25% of mild positive intracellular Hsp70 expression which consisted of 0 patient of stage I and III, 2 patients of stage II, and 3 patients of stage IV. Followed by 50% of moderate positive intracellular Hsp70 expression which consisted of 0 patient of stage I and II, 1 patient of stage III, and 9 patients of stage IV. Spearman test results test scored p = 0.001 with a correlation coefficient of 0.671. The correlation of intracellular Hsp70 protein expression with stage (I, II, III, and IV) in NPC patients was significant (p < 0.05). There was a correlation between increased intracellular Hsp70 expression and the stage of patients with nasopharyngeal carcinoma.


Nasopharyngeal carcinoma Intracellular Hsp70 protein expression Staging status 


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Copyright information

© Association of Otolaryngologists of India 2018

Authors and Affiliations

  • Elida Mustikaningtyas
    • 1
  • Sri Herawati Juniati
    • 1
    Email author
  • A. C. Romdhoni
    • 1
  1. 1.Department of Otolaryngology, Faculty of MedicineUniversitas Airlangga, Dr. Soetomo General HospitalSurabayaIndonesia

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