Proton Beam Therapy for Locally Recurrent Parotid Gland Cancer
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The aim of this study was to evaluate the efficacy and safety of proton beam therapy for patients with locally recurrent parotid cancer. Between 2009 and 2012, ten patients with locally recurrent parotid gland cancer were treated with proton beam therapy (70.2 Gy equivalents in 32 fractions) with or without intra-arterial infusion chemotherapy of cisplatin (50 mg/body/week, for a total of 5–8 weeks). The median follow-up was 24 months (range 10–49 months). The 1-year overall survival and local control rates were 80 %, and the 3-year overall survival and local control rates were 60 %. None of the patients experienced grade 3–5 toxicities in the treatment or the follow-up periods. These findings suggest that proton beam therapy could be applied effectively and safely for patients with locally recurrent parotid gland cancer.
KeywordsIntra-arterial chemotherapy Local recurrence Parotid gland cancer Proton beam therapy Re-irradiation
Compliance with Ethical Standards
Conflict of interest
All authors have no conflicts of interest to declare.
This study is a retrospective study. Therefore, this type of study formal consent is not required.
Human and Animal Rights
This article does not contain any studies with animals performed by any of the authors.
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