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Evaluation of Liver Functions Based on Serum Aminotransferase Enzyme Levels in Patients with Obstructive Sleep Apnea Syndrome

  • Doğan AtanEmail author
  • Sabri Köseoğlu
  • Kürşat Murat Özcan
  • Aykut İkincioğulları
  • Ayşe Betül Topak
  • İbrahim Özcan
  • Hüseyin Dere
Original Article
  • 57 Downloads

Abstract

Obstructive sleep apnea syndrome (OSAS) is associated with fatty liver disease. In the present study, relations between alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and the severity of OSAS and polysomnography parameters were investigated. The study included 194 patients with OSAS and 114 control patients. The patients underwent an overnight polysomnography (PSG) in the Sleep Laboratory. ALT and AST levels were compared between the patients and the controls and between the subgroups of the patients. ALT and AST levels were also compared with the PSG parameters REM AHI, NREM AHI and minimum O2 saturation separately. The mean ALT was 28.95 in the patients and 17.85 in the controls (p < 0.001) with a statistically significant difference and the mean AST was 23.62 in the patients and 16.53 in the controls with a statistically significant difference (p < 0.001). The patients with OSAS had significantly higher ALT and AST levels. The higher the ALT and AST levels were, the more severe the disease was, though the differences between the subgroups of the patients were not significant.

Keywords

Sleep apnea Aspartate aminotransferase Alanine aminotransferase Polysomnography 

Notes

Compliance with Ethical Standards

Conflict of interest

There are no conflicts of interest.

References

  1. 1.
    Türkay C, Ozol D, Kasapoğlu B, Kirbaş I, Yıldırım Z, Yiğitoğlu R (2012) Influence of obstructive sleep apnea on fatty liver disease: role of chronic intermittent hypoxia. Respir Care 57:244–249PubMedGoogle Scholar
  2. 2.
    Lee RG (1989) Nonalcoholic steatohepatitis: a study of 49 patients. Hum Pathol 20:594–598CrossRefGoogle Scholar
  3. 3.
    Vgontzas AN, Bixler EO, Chrousos GP (2005) Sleep apnea is a manifestation of the metabolic syndrome. Sleep Med Rev 9:211–224CrossRefGoogle Scholar
  4. 4.
    Sass DA, Chang P, Chopra KB (2005) Nonalcoholic fatty liver disease: a clinical review. Dig Dis Sci 50:171–180CrossRefGoogle Scholar
  5. 5.
    Dempsey JA, Veasey SC, Morgan BJ, O’Donnell CP (2010) Pathophysiology of sleep apnea. Physiol Rev 90:47–112CrossRefGoogle Scholar
  6. 6.
    Kohler M, Stradling JR (2010) Mechanisms of vascular damage in obstructive sleep apnea. Nat Rev Cardiol 7:677–685CrossRefGoogle Scholar
  7. 7.
    Tanné F, Gagnadoux F, Chazouillères O et al (2005) Chronic liver injury during obstructive sleep apnea. Hepatology 41:1290–1296CrossRefGoogle Scholar
  8. 8.
    McNamara SG, Grunstein RR, Sullivan CE (1993) Obstructive sleep apnea. Thorax 48:754–764CrossRefGoogle Scholar
  9. 9.
    Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328:1230–1235CrossRefGoogle Scholar
  10. 10.
    Greene JS, Zipfel TE, Harlor M (2004) The effect of uvulopalatopharyngoplasty on the nasality of voice. J Voice 18:423–430CrossRefGoogle Scholar
  11. 11.
    Day CP, Saksena S (2002) Non-alcoholic steatohepatitis: definitions and pathogenesis. J Gastroenterol Hepatol 17:377–384CrossRefGoogle Scholar
  12. 12.
    Daltro C, Cotrim HP, Alves E et al (2010) Nonalcoholic fatty liver disease associated with obstructive sleep apnea: just a coincidence? Obes Surg 20:1536–1543CrossRefGoogle Scholar
  13. 13.
    Byrne TJ, Parish JM, Somers V, Aqel BA, Rakela J (2012) Evidence for liver injury in the setting of obstructive sleep apnea. Ann Hepatol 11:228–231CrossRefGoogle Scholar
  14. 14.
    Norman D, Bardwell WA, Arosemena F et al (2008) Serum aminotransferase levels are associated with markers of hypoxia in patients with obstructive sleep apnea. Sleep 31:121–126CrossRefGoogle Scholar

Copyright information

© Association of Otolaryngologists of India 2015

Authors and Affiliations

  • Doğan Atan
    • 1
    Email author
  • Sabri Köseoğlu
    • 2
  • Kürşat Murat Özcan
    • 1
  • Aykut İkincioğulları
    • 1
  • Ayşe Betül Topak
    • 1
  • İbrahim Özcan
    • 3
  • Hüseyin Dere
    • 1
  1. 1.Ankara Numune Education and Research HospitalAnkaraTurkey
  2. 2.Tarsus State HospitalMersinTurkey
  3. 3.Kayseri Education and Research HospitalKayseriTurkey

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