Evaluation of Liver Functions Based on Serum Aminotransferase Enzyme Levels in Patients with Obstructive Sleep Apnea Syndrome

  • Doğan AtanEmail author
  • Sabri Köseoğlu
  • Kürşat Murat Özcan
  • Aykut İkincioğulları
  • Ayşe Betül Topak
  • İbrahim Özcan
  • Hüseyin Dere
Original Article


Obstructive sleep apnea syndrome (OSAS) is associated with fatty liver disease. In the present study, relations between alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and the severity of OSAS and polysomnography parameters were investigated. The study included 194 patients with OSAS and 114 control patients. The patients underwent an overnight polysomnography (PSG) in the Sleep Laboratory. ALT and AST levels were compared between the patients and the controls and between the subgroups of the patients. ALT and AST levels were also compared with the PSG parameters REM AHI, NREM AHI and minimum O2 saturation separately. The mean ALT was 28.95 in the patients and 17.85 in the controls (p < 0.001) with a statistically significant difference and the mean AST was 23.62 in the patients and 16.53 in the controls with a statistically significant difference (p < 0.001). The patients with OSAS had significantly higher ALT and AST levels. The higher the ALT and AST levels were, the more severe the disease was, though the differences between the subgroups of the patients were not significant.


Sleep apnea Aspartate aminotransferase Alanine aminotransferase Polysomnography 


Compliance with Ethical Standards

Conflict of interest

There are no conflicts of interest.


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Copyright information

© Association of Otolaryngologists of India 2015

Authors and Affiliations

  • Doğan Atan
    • 1
    Email author
  • Sabri Köseoğlu
    • 2
  • Kürşat Murat Özcan
    • 1
  • Aykut İkincioğulları
    • 1
  • Ayşe Betül Topak
    • 1
  • İbrahim Özcan
    • 3
  • Hüseyin Dere
    • 1
  1. 1.Ankara Numune Education and Research HospitalAnkaraTurkey
  2. 2.Tarsus State HospitalMersinTurkey
  3. 3.Kayseri Education and Research HospitalKayseriTurkey

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