Role of Oral Enzymes in Post Operative Septoplasty Cases

  • Manpreet Singh NandaEmail author
  • Mandeep Kaur
Original Article


Enzymes are complex macromolecules of amino acids which biocatalyse various body processes. The aim of this study is to evaluate the effect of oral enzymes for control of infection and inflammation in post operative septoplasty cases. 40 patients planned for septoplasty under general anaesthesia were taken up for study. 20 patients were included in group E and were given a combination of oral enzymes postoperatively. Remaining 20 patients were included in group D and were given diclofenac and paracetamol combination postoperatively. Patients were evaluated post operatively after 1, 2 and 4 weeks for post operative pain , swelling , congestion , patient satisfaction and other criterias. The results showed that pain and swelling was significantly less in oral enzymes group . There was less nasal obstruction , discharge and more patient satisfaction in enzyme group. There were less complications in enzyme group. So it can be concluded that oral enzymes are more effective for control of infection and inflammation in post operative septoplasty cases.


Septoplasty Bromelain Trypsin Rutoside Post operative pain Inflammation 



We would like to thank our institute Maharishi Markandeshwar Medical College and Hospital for its support and the patients for cooperating with the study protocol.

Conflict of interest

The authors declare that there is no conflict of interest.


  1. 1.
    Sener M, Yilmaz I, Bozdogan N, Ozer C, Donmez A et al (2008) Efficacy of lornoxicam for acute postoperative pain relief after septoplasty : a comparison with diclofenac, ketoprofen, and dipyrone. J Clin Anesth 20:103–108CrossRefGoogle Scholar
  2. 2.
    White PF (2005) The changing role of non- opoid analgesic techniques in the management of postoperative pain. Anesth Analg 101:5–22CrossRefGoogle Scholar
  3. 3.
    Holdgate A, Pollock T (2004) Systemic review of the relative efficacy of non-steroidal anti-inflammatory drugs and opoids in the treatment of acute renal colin. BMJ 328:1401CrossRefGoogle Scholar
  4. 4.
    Lopez DA, William RM, Miehike M (1994) Enzymes: the fountain of life. The Neville Press Inc, Charleston SCGoogle Scholar
  5. 5.
    Seltzer AP (1967) Adjunctive use of bromelains in sinusitis. Eye Ear Nose Throat Monthly 46:1281–1288PubMedGoogle Scholar
  6. 6.
    Mazzone A, Catalani M, Constanzo M, Drusian A, Russo S et al (1990) Evaluation of Serratipeptidase in acute or chronic inflammation of otorhinolaryngolog pathology: a multicentre,double—blind, randomized trial versus placebo. J Int Med Res 18(5):379–388CrossRefGoogle Scholar
  7. 7.
    Friess H, Kleeff J, Malfertheiner P, Muller MW, Homuth K, Buchler MW (1998) Influence of high dose pancreatic enzyme treatment on pancreatic function in healthy volunteers. Int J Pancreatol 23(2):115–123CrossRefGoogle Scholar
  8. 8.
    Taussig SJ, Batkin S (1988) Bromelain, the enzyme complex of pineapple (Ananus comosus) and its clinical application: An update. J Ethnopharmacol 22:191–203CrossRefGoogle Scholar
  9. 9.
    Barth H, Guseo A, Klein R (2005) In vitro study on immunological effects of bromelain and trypsin on mononuclear cells from humans. Eur J Med Res 10:325–331PubMedGoogle Scholar
  10. 10.
    Taussig SJ (1980) The mechanism of the physiological action of bromelain. Med Hypothesis 6(1):99–104CrossRefGoogle Scholar
  11. 11.
    Shahid SK, Turakhia NH, Kundra M, Shanbag P, Daftary GV, Schiess W (2002) Efficacy and safety of Phlogenzym-A protease formulation in sepsis in children. JAPI 50:527–531PubMedGoogle Scholar
  12. 12.
    La Cassa C, Villegas I, Alacron de la Lastra C, Motilva V, Martin Calero MJ (2000) Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. J Ethnopharmacol 71:45–53CrossRefGoogle Scholar
  13. 13.
    Neubauer RA (1961) A plant protease for potentiation of and possible replacement of antibiotics. Exp Med Surg 19:143–160PubMedGoogle Scholar
  14. 14.
    Falanga V (2002) Wound bed preparation and the role of enzymes: A case for multiple actions of therapeutic agents. Wounds 14:47–57Google Scholar
  15. 15.
    Baskanchiladze GS, Khurtsilava LA, Gelovani IA, Asatiani MV, Rossinskii VI (1984) Chemotherapeutic effectiveness of antibioticsin combination with papain in experimental septicaemia. Antibiotiki 29(1):33–35PubMedGoogle Scholar
  16. 16.
    Ishikawa H, Oguro Y (1974) Protective effect of stem-bromelain in combination with antibiotics on experimental infection in mice induced by Streptococcus hemolyticus, Diplococcus pneumonia or Pseudomonas aeruginosa. Jpn J Antibiot 27(2):118–121PubMedGoogle Scholar

Copyright information

© Association of Otolaryngologists of India 2014

Authors and Affiliations

  1. 1.Department of Otolaryngology – Head and Neck SurgeryMaharishi Markandeshwar Medical College & Hospital, KumarahattiSolanIndia
  2. 2.Department of AnaesthesiaMaharishi Markandeshwar Medical College & Hospital, KumarahattiSolanIndia

Personalised recommendations