Advertisement

Resonance

, Volume 24, Issue 3, pp 289–296 | Cite as

Cell Mechanosensing

Response of Living Cells to Their Mechanical Environment
General Article
  • 1 Downloads

Abstract

Mechanical forces are known to play important roles in determining cellular functions and behaviours such as growth, migration, wound healing and tissue regeneration, to name a few. It is quite intriguing how cells sense the mechanical forces and properties of the surrounding matrix in which the cells float or rest. The cells are known to build numerous ‘adhesion contacts’ at the cell-matrix interface to probe the surroundings. These adhesion contacts, known as ‘focal adhesions’ are highly dynamic and strongly force sensitive. In this article, we discuss about the focal adhesions which act as mechanosensors and, in turn, regulate cellular activity.

Keywords

Mechanobiology cell adhesion molecular bond dynamics stochastic process master equation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Suggested Reading

  1. [1]
    T Iskratsch, H Wolfenson and M P Sheetz, Appreciating Force and Shape — The Rise of Mechanotransduction in Cell Biology, Nature Rev. Mol Cell Biol., Vol.12, pp.825–833, 2014.CrossRefGoogle Scholar
  2. [2]
    B Geiger, J P Spatz and A D Bershadsky, Environmental Sensing Through Focal Adhesions, Nature Rev. Mol. Cell Biol., Vol.10, pp.21–33, 2009.CrossRefGoogle Scholar
  3. [3]
    U S Schwarz and S A Safran, Physics of Adherent Cells, Rev. Mod. Phys., Vol.85, pp.1327–1381, 2013.CrossRefGoogle Scholar
  4. [4]
    R De, A Zemel, and S A Safran, Theoretical Concepts and Models of Cellular Mechanosensing, Methods Cell Biol., Vol.98, pp.143–175, 2010.CrossRefGoogle Scholar
  5. [5]
    D E Discher, P Janmey and Y L Wang, Tissue Cells Feel and Respond to the Stiffness of Their Substrate, Science, Vol.18, pp.1139–1143, 2005.CrossRefGoogle Scholar
  6. [6]
    R De, A Zemel and S A Safran, Dynamics of Cell Orientation, Nature Physics, Vol.3, pp.655–659, 2007.CrossRefGoogle Scholar
  7. [7]
    R De, A General Model of Focal Adhesion Orientation Dynamics in Response to Static and Cyclic Stretch, Communications Biology, Vol.1, Article No. 81, 2018.Google Scholar
  8. [8]
    W E Thomas, V Vogel and E Sokurenko, Biophysics of Catch Bonds, Annu. Rev. Biophys., Vol.37, pp.399–416, 2008.CrossRefGoogle Scholar
  9. [9]
    G I Bell, Models for the Specific Adhesion of Cells to Cells, Science, Vol.200, pp.618–627, 1978.CrossRefGoogle Scholar
  10. [10]
    Y Pereverzev, O V Prezhdo, M Forero, E Sokurenko and W Thomas, The Two-pathway Model for the Catch-slip Transition in Biological Adhesion, Biophys. J., Vol.89, pp.1446–1454, 2005.CrossRefGoogle Scholar
  11. [11]
    N G Van Kampen, Stochastic Processes in Physics and Chemistry, Elsevier, 2011.Google Scholar
  12. [12]
    D T Gillespie, Exact Stochastic Simulation of Coupled Chemical Reactions, J. Phys. Chem., Vol.81, pp.2340–2361, 1977.CrossRefGoogle Scholar

Copyright information

© Indian Academy of Sciences 2019

Authors and Affiliations

  1. 1.Department of Physical SciencesIndian Institute of Science Education and ResearchKolkata, MohanpurIndia

Personalised recommendations