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Resonance

, Volume 23, Issue 12, pp 1343–1358 | Cite as

Nobel Prize in Chemistry – 2018

Speeding Up Protein Evolution
  • Purnananda Guptasarma
General Article
  • 9 Downloads

Abstract

The 2018 Nobel Prize for Chemistry rewards research on the use of bacteria and viruses to generate and screen highly diverse protein sequences for improved catalytic and ligandbinding function. One half of the Prize was awarded to Professor Frances Arnold of the California Institute of Technology (California, USA). The other half was awarded jointly to Professor George P Smith of the University of Missouri (Columbia, USA) and Professor Sir Gregory P Winter of the Medical Research Council’s Laboratory of Molecular Biology (Cambridge, UK). The three winners have been amongst the tallest of stalwarts in combinatorial approaches to protein engineering.

Keywords

Phage-display bacteriophage error-prone PCR mutation phagemid combinatorial library biopanning gene amplification antibodies protein engineering 

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Suggested Reading

  1. [1]
    L Pritchard et.al., A General Model of Error-prone PCR, J Theor Biol., 234(4), pp.497–509, 21 June 2005.CrossRefGoogle Scholar
  2. [2]
    Justine Bazan, Ireneusz Calkosinski, and Andrzej Gamian, Phage Display–A Powerful Technique for Immunotherapy, Hum Vaccin Immunother., 8(12), pp.1817–1828, 1 Dec 2012.CrossRefGoogle Scholar

Copyright information

© Indian Academy of Sciences 2018

Authors and Affiliations

  1. 1.Centre for Protein Science, Design and Engineering (CPSDE) Department of Biological SciencesIndian Institute of Science Education and Research (IISER) MohaliSAS NagarIndia

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