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Journal of Chemical Sciences

, 131:105 | Cite as

Development of novel pyrazolones by using SiO2/ZnCl2 – green approach

  • G Neelima
  • K Lakshmi
  • K Sesha MaheswarammaEmail author
Regular Article
  • 13 Downloads

Abstract

The present research work deals with the green synthesis of substituted pyrazolone derivatives 4(a–f) from 2,4-dinitrophenylhydrazine with various substituted aromatic aldehyde and ethyl acetoacetate in the presence of silica-supported zinc chloride (SiO2/ZnCl2) as a recyclable Lewis acid catalyst. The synthesized compounds were structurally characterized with IR, 1H NMR, Mass spectra and elemental analysis. All these compounds were tested for their antioxidant activity by using the DPPH radical scavenging method.

Graphic abstract

Synthetic Scheme of pyrazolone derivatives

Keywords

Pyrazolone silica-supported zinc chloride catalyst green synthesis anti-oxidant activity 

Notes

Acknowledgements

The authors thank the Management and the Principal of Sri Venkateswara College of Pharmacy, Chittoor for providing the facilities and financial assistance to carry out this study. They are also thankful to SIF, VIT University, Vellore for the spectral analysis.

Supplementary material

12039_2019_1679_MOESM1_ESM.pdf (797 kb)
Supplementary material 1 (PDF 798 kb)

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Copyright information

© Indian Academy of Sciences 2019

Authors and Affiliations

  1. 1.JNTU, AnanthapuramuAnantapurIndia
  2. 2.Department of Pharmaceutical AnalysisSri Venkateswara College of PharmacyChittoorIndia
  3. 3.Department of ChemistryJNTU College of Engineering (Autonomous) PulivendulaPulivendulaIndia

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