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Journal of Chemical Sciences

, 131:90 | Cite as

Microneedle-based drug delivery: materials of construction

  • Shubhmita Bhatnagar
  • Pradeeptha Reddy Gadeela
  • Pranathi Thathireddy
  • Venkata Vamsi Krishna VenugantiEmail author
Regular Article
  • 177 Downloads

Abstract

Microneedle-based drug delivery has attracted researchers’ attention over the last decade. The material of construction of microneedles has emerged as a critical factor influencing clinical usage, manufacture, drug loading and drug stability. Initially, microneedles were fabricated using glass, silicon and metals. The development of sophisticated machining tools and advances in the polymer science allowed for a major shift in materials of construction of microneedles towards polymeric systems. Delivery of difficult to formulate therapeutics, including proteins, peptides, vaccines and genetic material has been established using microneedles. There is a constant search for newer materials, which can easily form microneedles with sufficient strength to penetrate biological barriers, can be easily manufactured, and are compatible with drug molecules and biological systems. While several reviews have discussed microneedle-based cosmetic and drug delivery applications, there is a gap in understanding the effect of material of construction of microneedles on drug stability and potential for large-scale manufacture. This review is an attempt to present microneedles as a function of the material used for its construction. Since microneedle commercialization is now a realistic possibility, we believe that improved understanding of materials and their chemistry will allow for improved decision making, especially for industries looking towards bringing microneedle technology to manufacturing setups.

Graphical abstract

Microneedles (MN) bypass the superficial skin layers to deliver molecules to deeper tissues. The material of MN construction has emerged as a critical factor influencing cost, clinical usage, manufacture, drug loading and drug stability. Currently available materials and techniques for MN fabrication and their relevance to scale-up are reviewed.

Keywords

Microneedles materials microfabrication transdermal drug delivery tensile strength 

Notes

Acknowledgements

This work was partially funded by the Indian Council of Medical Research (ICMR, ITR 2015-0010).

References

  1. 1.
    Blanco E, Shen H and Ferrari M 2015 Principles of nanoparticle design for overcoming biological barriers to drug delivery Nat. Biotechnol. 33 941Google Scholar
  2. 2.
    Bhatnagar S, Dave K and Venuganti V V K 2017 Microneedles in the clinic J. Control Release 260 164PubMedGoogle Scholar
  3. 3.
    Kim Y C, Park J H and Prausnitz M R 2012 Microneedles for drug and vaccine delivery Adv. Drug Deliv. Rev. 64 1547Google Scholar
  4. 4.
    Traverso G, Schoellhammer C M, Schroeder A, Maa R, Lauwers G Y, Polat B E, Anderson D G, Blankschtein D and Langer R 2015 Microneedles for drug delivery via the gastrointestinal tract J. Pharm. Sci. 104 362PubMedGoogle Scholar
  5. 5.
    Jiang J, Gill H S, Ghate D, McCarey B E, Patel S R, Edelhauser H F and Prausnitz M R 2007 Coated microneedles for drug delivery to the eye Invest. Ophthalmol. Vis. Sci. 48 4038Google Scholar
  6. 6.
    Larrañeta E, Lutton R E M, Woolfson A D and Donnelly R F 2016 Microneedle arrays as transdermal and intradermal drug delivery systems: materials science, manufacture and commercial development Mater. Sci. Eng. R Rep. 104 1Google Scholar
  7. 7.
    Pamornpathomkul B, Ngawhirunpat T, Tekko I A, Vora L, McCarthy H O and Donnelly R F 2018 Dissolving polymeric microneedle arrays for enhanced site-specific acyclovir delivery Eur. J. Pharm. Sci. 121 200Google Scholar
  8. 8.
    Mukerjee E V, Collins S D, Isseroff R R and Smith R L 2004 Microneedle array for transdermal biological fluid extraction and in situ analysis Sens. Actuat. A Phys. 114 267Google Scholar
  9. 9.
    Donnelly R F, Mooney K, McCrudden M T, Vicente-Perez E M, Belaid L, Gonzalez-Vazquez P, McElnay J C and Woolfson A D 2014 Hydrogel-forming microneedles increase in volume during swelling in skin, but skin barrier function recovery is unaffected J. Pharm. Sci. 103 1478PubMedPubMedCentralGoogle Scholar
  10. 10.
    Henstock J R, Canham L T and Anderson S I 2015 Silicon: the evolution of its use in biomaterials Acta Biomater. 11 17PubMedGoogle Scholar
  11. 11.
    Donnelly R F, Morrow D I J, Fay F, Scott C J, Abdelghany S, Singh R R T, Garland M J and David Woolfson A 2010 Microneedle-mediated intradermal nanoparticle delivery: potential for enhanced local administration of hydrophobic pre-formed photosensitisers Photodiagn. Photodyn. Ther. 7 222PubMedGoogle Scholar
  12. 12.
    Hench L L and Wilson J 1986 Biocompatibility of silicates for medical use Ciba Found Symp. 121 231PubMedGoogle Scholar
  13. 13.
    Iacocca R G, Toltl N, Allgeier M, Bustard B, Dong X, Foubert M, Hofer J, Peoples S and Shelbourn T 2010 Factors affecting the chemical durability of glass used in the pharmaceutical industry AAPS PharmSciTech 11 1340PubMedPubMedCentralGoogle Scholar
  14. 14.
    Chambers R and Chambers E L 1961 Explorations into the nature of the living cell Acad. Med. 36 966Google Scholar
  15. 15.
    Poggesi C, Tesi C and Stehle R 2005 Sarcomeric determinants of striated muscle relaxation kinetics Pflügers Archiv 449 505Google Scholar
  16. 16.
    Tombe P P D, Belus A, Piroddi N, Scellini B, Walker J S, Martin A F, Tesi C and Poggesi C 2007 Myofilament calcium sensitivity does not affect cross-bridge activation-relaxation kinetics Am. J. Physiol. Regul. Integr. Comp. Physiol. 292 R1129Google Scholar
  17. 17.
    Gupta J, Felner E I and Prausnitz M R 2011 Rapid pharmacokinetics of intradermal insulin administered using microneedles in type 1 diabetes subjects Diabetes Technol. Ther. 13 451Google Scholar
  18. 18.
    Wang P M, Cornwell M and Prausnitz M R 2005 Minimally invasive extraction of dermal interstitial fluid for glucose monitoring using microneedles Diabetes Technol. Ther. 7 131Google Scholar
  19. 19.
    Wang P M, Cornwell M, Hill J and Prausnitz M R 2006 Precise microinjection into skin using hollow microneedles J. Invest. Dermatol. 126 1080PubMedGoogle Scholar
  20. 20.
    Ayittey P N, Walker J S, Rice J J and De Tombe P P 2009 Glass microneedles for force measurements: a finite-element analysis model Pflugers Arch. 457 1415PubMedGoogle Scholar
  21. 21.
    http://www.grantadesign.com. Accessed 16 March 2019
  22. 22.
    Bouras N, Madjoubi M, Kolli M, Benterki S and Hamidouche M 2009 Thermal and mechanical characterization of borosilicate glass Phys. Procedia 2 1135Google Scholar
  23. 23.
    Ashby M F 2012 Materials and the Environment: Eco-informed Material Choice (Oxford: Elsevier)Google Scholar
  24. 24.
    Hopcroft M A, Nix W D and Kenny T W 2010 What is the Young’s modulus of silicon? J. Microelectromech. Syst. 19 229Google Scholar
  25. 25.
    Petersen K E 1982 Silicon as a mechanical material P. IEEE 70 420Google Scholar
  26. 26.
    Giallonardo J D, Erb U, Aust K T and Palumbo G 2011 The influence of grain size and texture on the Young’s modulus of nanocrystalline nickel and nickel-iron alloys Philos. Mag. 91 4594Google Scholar
  27. 27.
    Meshram S D, Mohandas T and Reddy G M 2007 Friction welding of dissimilar pure metals J. Mater. Process. Technol. 184 330Google Scholar
  28. 28.
    Zhou Y L, Niinomi M and Akahori T 2004 Dynamic Young’s modulus and mechanical properties of Ti–Hf alloys Mater. Trans. 45 1549Google Scholar
  29. 29.
    Information from http://asm.matweb.com. Accessed on 16 March 2019
  30. 30.
    Seidemann V, Bütefisch S and Büttgenbach S 2002 Fabrication and investigation of in-plane compliant SU8 structures for MEMS and their application to micro valves and micro grippers Sens. Actuat. A Phys. 97 457Google Scholar
  31. 31.
    Svensson R B, Hassenkam T, Grant C A and Magnusson S P 2010 Tensile properties of human collagen fibrils and fascicles are insensitive to environmental salts Biophys. J. 99 4020PubMedPubMedCentralGoogle Scholar
  32. 32.
    Buehler M J 2006 Nature designs tough collagen: explaining the nanostructure of collagen fibrils Proc. Natl. Acad. Sci. USA 103 12285Google Scholar
  33. 33.
    Oun A A and Rhim J-W 2015 Preparation and characterization of sodium carboxymethyl cellulose/cotton linter cellulose nanofibril composite films Carbohydr. Polym. 127 101Google Scholar
  34. 34.
    Engelberg I and Kohn J 1991 Physico-mechanical properties of degradable polymers used in medical applications: a comparative study Biomaterials 12 292PubMedGoogle Scholar
  35. 35.
    Gentile P, Chiono V, Carmagnola I and Hatton P V 2014 An overview of poly(lactic-co-glycolic) acid (PLGA)-based biomaterials for bone tissue engineering Int. J. Mol. Sci. 15 3640PubMedPubMedCentralGoogle Scholar
  36. 36.
    Gong S, Wang H, Sun Q, Xue S-T and Wang J-Y 2006 Mechanical properties and in vitro biocompatibility of porous zein scaffolds Biomaterials 27 3793PubMedGoogle Scholar
  37. 37.
    Mandapalli P K, Labala S, Chawla S, Janupally R, Sriram D and Venuganti V V K 2017 Polymer–gold nanoparticle composite films for topical application: evaluation of physical properties and antibacterial activity Polym. Compos. 38 2829Google Scholar
  38. 38.
    K Chan, H Senin and I Naimah 2009 (Eds.) Structural And Mechanical Properties Of Polyvinyl Alcohol (Pva) Thin Film. AIP Conference Proceedings; 2009: AIPGoogle Scholar
  39. 39.
    Bauccio M 1994 ASM Engineered Materials Reference Book (Ohio: ASM International)Google Scholar
  40. 40.
    Orlovskii V, Komlev V and Barinov S 2002 Hydroxyapatite and hydroxyapatite-based ceramics Inorg. Mater. 38 973Google Scholar
  41. 41.
    Evis Z and Ozturk F 2008 Investigation of tensile strength of hydroxyapatite with various porosities by diametral strength test Mater. Sci. Tech. 24 474Google Scholar
  42. 42.
    Jeon O, Song S J, Lee K-J, Park M H, Lee S-H, Hahn S K, Kim S and Kim B-S 2007 Mechanical properties and degradation behaviors of hyaluronic acid hydrogels cross-linked at various cross-linking densities Carbohydr. Polym. 70 251Google Scholar
  43. 43.
    Liu M, Sun J, Sun Y, Bock C and Chen Q 2009 Thickness-dependent mechanical properties of polydimethylsiloxane membranes J. Micromech. Microeng. 19 035028Google Scholar
  44. 44.
    Czerner M, Fellay L S, Suárez M P, Frontini P M and Fasce L A 2015 Determination of elastic modulus of gelatin gels by indentation experiments Procedia Mater. Sci. 8 287Google Scholar
  45. 45.
    Rhim J-W 2004 Physical and mechanical properties of water resistant sodium alginate films LWT Food Sci. Technol. 37 323Google Scholar
  46. 46.
    Hermawan H, Ramdan D and Djuansjah J R 2011 Metals for biomedical applications. Biomedical engineering-from theory to applications: InTech; 2011Google Scholar
  47. 47.
    Loizidou E Z, Williams N A, Barrow D A, Eaton M J, McCrory J, Evans S L and Allender C J 2015 Structural characterisation and transdermal delivery studies on sugar microneedles: Experimental and finite element modelling analyses Eur. J. Pharm. Biopharm. 89 224Google Scholar
  48. 48.
    Devi S and Williams D 2013 Morphological and compressional mechanical properties of freeze-dried mannitol, sucrose, and trehalose cakes J. Pharm. Sci. 102 4246PubMedGoogle Scholar
  49. 49.
    Yoshinari T, Forbes R T, York P and Kawashima Y 2003 The improved compaction properties of mannitol after a moisture-induced polymorphic transition Int. J. Pharm. 258 121Google Scholar
  50. 50.
    Raphael A P, Crichton M L, Falconer R J, Meliga S, Chen X, Fernando G J P, Huang H and Kendall M A F 2016 Formulations for microprojection/microneedle vaccine delivery: structure, strength and release profiles J. Control Release 225 40PubMedGoogle Scholar
  51. 51.
    Demir Y K, Akan Z and Kerimoglu O 2013 Characterization of polymeric microneedle arrays for transdermal drug delivery PLoS ONE 8 e77289PubMedGoogle Scholar
  52. 52.
  53. 53.
  54. 54.
    Radhakrishnan J, Padaki V and Singh U 2017 Mechanical failure analysis of needles, for micro-needle array dry-electrodes Def. Life Sci. J. 2 448Google Scholar
  55. 55.
    Information from http://www.mit.edu/~6.777/matprops/alox.htm. Accessed on 14 March 2019
  56. 56.
    Information from https://www.engineeringtoolbox.com/polymer-properties-d_1222.html. Accessed on 14 March 2019
  57. 57.
    Information from http://www.designerdata.nl/plastics/thermo+plastics/PMMA. Accessed on 14 March 2019
  58. 58.
    Manivasagam G, Dhinasekaran D and Rajamanickam A 2010 Biomedical implants: corrosion and its prevention—a review Recent Pat. Corros. Sci. 2 40Google Scholar
  59. 59.
    Brandes E A and Brook G (Eds.) 2013 Smithells Metals Reference Book (Oxford: Butterworth-Heinemann)Google Scholar
  60. 60.
    Niinomi M 1998 Mechanical properties of biomedical titanium alloys Mater. Sci. Eng. A 243 231Google Scholar
  61. 61.
    Balagna C, Spriano S and Faga M G 2012 Characterization of Co–Cr–Mo alloys after a thermal treatment for high wear resistance Mater. Sci. Eng. C 32 1868Google Scholar
  62. 62.
    van der Maaden K, Jiskoot W and Bouwstra J 2012 Microneedle technologies for (trans)dermal drug and vaccine delivery J. Control Release 161 645PubMedGoogle Scholar
  63. 63.
    Dharadhar S, Majumdar A, Dhoble S and Patravale V 2019 Microneedles for transdermal drug delivery: a systematic review Drug Dev. Ind. Pharm. 45 188Google Scholar
  64. 64.
    Vinayakumar K B, Hegde G M, Nayak M M, Dinesh N S and Rajanna K 2014 Fabrication and characterization of gold coated hollow silicon microneedle array for drug delivery Microelectron. Eng. 128 12Google Scholar
  65. 65.
    Mikszta J A, Alarcon J B, Brittingham J M, Sutter D E, Pettis R J and Harvey N G 2002 Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery Nat. Med. 8 415Google Scholar
  66. 66.
    McAllister D V, Wang P M, Davis S P, Park J-H, Canatella P J, Allen M G and Prausnitz M R 2003 Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: fabrication methods and transport studies Proc. Natl. Acad. Sci USA 100 13755Google Scholar
  67. 67.
    Gill H S and Prausnitz M R 2007 Coated microneedles for transdermal delivery J. Control Release 117 227PubMedGoogle Scholar
  68. 68.
    Daddona P E, Matriano J A, Mandema J and Maa Y-F 2011 Parathyroid hormone (1–34)-coated microneedle patch system: clinical pharmacokinetics and pharmacodynamics for treatment of osteoporosis Pharm. Res. 28 159Google Scholar
  69. 69.
    Boks M A, Unger W W, Engels S, Ambrosini M, van Kooyk Y and Luttge R 2015 Controlled release of a model vaccine by nanoporous ceramic microneedle arrays Int. J. Pharm. 491 375Google Scholar
  70. 70.
    Cai B, Xia W, Bredenberg S, Li H and Engqvist H 2015 Bioceramic microneedles with flexible and self-swelling substrate Eur. J. Pharm. Biopharm. 94 404Google Scholar
  71. 71.
    Barsoum M and Barsoum M 2002 Fundamentals of Ceramics (New York: Taylor and Francis)Google Scholar
  72. 72.
    Krajewski A, Ravaglioli A, Roncari E, Pinasco P and Montanari L 2000 Porous ceramic bodies for drug delivery J. Mater. Sci. Mater. Med. 11 763PubMedGoogle Scholar
  73. 73.
    Olhero S, Lopes E and Ferreira J 2016 Fabrication of ceramic microneedles—the role of specific interactions between processing additives and the surface of oxide particles in Epoxy Gel Casting J. Eur. Ceram. Soc. 36 4131Google Scholar
  74. 74.
    Saini M, Singh Y, Arora P, Arora V and Jain K 2015 Implant biomaterials: a comprehensive review World J. Clin. Cases 3 52Google Scholar
  75. 75.
    Yu W, Jiang G, Liu D, Li L, Chen H, Liu Y, Huang Q, Tong Z, Yao J and Kong X 2017 Fabrication of biodegradable composite microneedles based on calcium sulfate and gelatin for transdermal delivery of insulin Mater. Sci. Eng. C 71 725Google Scholar
  76. 76.
    Yu W, Jiang G, Liu D, Li L, Tong Z, Yao J and Kong X 2017 Transdermal delivery of insulin with bioceramic composite microneedles fabricated by gelatin and hydroxyapatite Mater. Sci. Eng. C 73 425Google Scholar
  77. 77.
    Metroke T L, Parkhill R L and Knobbe E T 2001 Passivation of metal alloys using sol–gel-derived materials—a review Prog. Org. Coat. 41 233Google Scholar
  78. 78.
    Cai B, Xia W, Bredenberg S and Engqvist H 2014 Self-setting bioceramic microscopic protrusions for transdermal drug delivery J. Mater. Chem. B 2 5992Google Scholar
  79. 79.
    Kolli C S and Banga A K 2008 Characterization of solid maltose microneedles and their use for transdermal delivery Pharm. Res. 25 104Google Scholar
  80. 80.
    Li G, Badkar A, Nema S, Kolli C S and Banga A K 2009 In vitro transdermal delivery of therapeutic antibodies using maltose microneedles Int. J. Pharm. 368 109Google Scholar
  81. 81.
    Kim H K, Lee S H, Lee B Y, Kim S J, Sung C Y, Jang N K, Kim J D, Jeong D H, Ryu H Y and Lee S 2018 A comparative study of dissolving hyaluronic acid microneedles with trehalose and poly(vinyl pyrrolidone) for efficient peptide drug delivery Biomater. Sci. 6 2566PubMedGoogle Scholar
  82. 82.
    Zhang Y, Jiang G, Yu W, Liu D and Xu B 2018 Microneedles fabricated from alginate and maltose for transdermal delivery of insulin on diabetic rats Mater. Sci. Eng. C 85 18Google Scholar
  83. 83.
    McGrath M G, Vucen S, Vrdoljak A, Kelly A, O’Mahony C, Crean A M and Moore A 2014 Production of dissolvable microneedles using an atomised spray process: effect of microneedle composition on skin penetration Eur. J. Pharm. Biopharm. 86 200Google Scholar
  84. 84.
    Martin C J, Allender C J, Brain K R, Morrissey A and Birchall J C 2012 Low temperature fabrication of biodegradable sugar glass microneedles for transdermal drug delivery applications J. Control Release 158 93PubMedGoogle Scholar
  85. 85.
    Bhatnagar S, Chawla S R, Kulkarni O P and Venuganti V V K 2017 Zein microneedles for transcutaneous vaccine delivery: fabrication, characterization, and in vivo evaluation using ovalbumin as the model antigen ACS Omega 2 1321PubMedPubMedCentralGoogle Scholar
  86. 86.
    Ito Y, Inagaki Y, Kobuchi S, Takada K and Sakaeda T 2016 Therapeutic drug monitoring of vancomycin in dermal interstitial fluid using dissolving microneedles Int. J. Med. Sci. 13 271Google Scholar
  87. 87.
    Zhu Z, Luo H, Lu W, Luan H, Wu Y, Luo J, Wang Y, Pi J, Lim C Y and Wang H 2014 Rapidly dissolvable microneedle patches for transdermal delivery of exenatide Pharm. Res. 31 3348Google Scholar
  88. 88.
    Chen B Z, Ashfaq M, Zhang X P, Zhang J N and Guo X D 2018 In vitro and in vivo assessment of polymer microneedles for controlled transdermal drug delivery J. Drug Targ. 26 720PubMedGoogle Scholar
  89. 89.
    Mishra R, Bhattacharyya T K and Maiti T K 2015 (Eds.) Theoretical analysis and simulation of SU-8 microneedles for effective skin penetration and drug delivery. 2015 IEEE Sensprs; 2015: IEEEGoogle Scholar
  90. 90.
    Mishra R, Maiti T K and Bhattacharyya T K 2018 Development of SU-8 hollow microneedles on a silicon substrate with microfluidic interconnects for transdermal drug delivery J. Micromech. Microeng. 28 105017Google Scholar
  91. 91.
    Sun W, Araci Z, Inayathullah M, Manickam S, Zhang X, Bruce M A, Marinkovich M P, Lane A T, Milla C and Rajadas J 2013 Polyvinylpyrrolidone microneedles enable delivery of intact proteins for diagnostic and therapeutic applications Acta Biomater. 9 7767PubMedGoogle Scholar
  92. 92.
    Lee I-C, Wu Y-C, Tsai S-W, Chen C-H and Wu M-H 2017 Fabrication of two-layer dissolving polyvinylpyrrolidone microneedles with different molecular weights for in vivo insulin transdermal delivery RSC Adv. 7 5067Google Scholar
  93. 93.
    Luzuriaga M A, Berry D R, Reagan J C, Smaldone R A and Gassensmith J J 2018 Biodegradable 3D printed polymer microneedles for transdermal drug delivery Lab Chip. 18 1223Google Scholar
  94. 94.
    Boehm R D, Daniels J, Stafslien S, Nasir A, Lefebvre J and Narayan R J 2015 Polyglycolic acid microneedles modified with inkjet-deposited antifungal coatings Biointerphases 10 011004PubMedGoogle Scholar
  95. 95.
    Park J-H, Allen M G and Prausnitz M R 2005 Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery J. Control Release 104 51PubMedGoogle Scholar
  96. 96.
    Andersen T E, Andersen A J, Petersen R S, Nielsen L H and Keller S S 2018 Drug loaded biodegradable polymer microneedles fabricated by hot embossing Microelectron. Eng. 195 57Google Scholar
  97. 97.
    Choi S-O, Kim Y C, Park J-H, Hutcheson J, Gill H S, Yoon Y-K, Prausnitz M R and Allen M G 2010 An electrically active microneedle array for electroporation Biomed. Microdev. 12 263Google Scholar
  98. 98.
    Oh J-H, Park H-H, Do K-Y, Han M, Hyun D-H, Kim C-G, Kim C-H, Lee S S, Hwang S-J and Shin S-C 2008 Influence of the delivery systems using a microneedle array on the permeation of a hydrophilic molecule, calcein Eur. J. Pharm. Biopharm. 69 1040Google Scholar
  99. 99.
    Sharma S, Saeed A, Johnson C, Gadegaard N and Cass A E 2017 Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring Sens. Bio Sens. Res. 13 104Google Scholar
  100. 100.
    Martin A, McConville A, Anderson A, McLister A and Davis J 2017 Microneedle manufacture: assessing hazards and control measures Safety 3 25Google Scholar
  101. 101.
    Luangveera W, Jiruedee S, Mama W, Chiaranairungroj M, Pimpin A, Palaga T and Srituravanich W 2015 Fabrication and characterization of novel microneedles made of a polystyrene solution J. Mech. Behav. Biomed. Mater. 50 77PubMedGoogle Scholar
  102. 102.
    McCrudden M T, Alkilani A Z, McCrudden C M, McAlister E, McCarthy H O, Woolfson A D and Donnelly R F 2014 Design and physicochemical characterisation of novel dissolving polymeric microneedle arrays for transdermal delivery of high dose, low molecular weight drugs J. Control Release 180 71PubMedPubMedCentralGoogle Scholar
  103. 103.
    Hanna K, Yasar-Inceoglu O and Yasar O 2018 Drug delivered poly(ethylene glycol) diacrylate (PEGDA) hydrogels and their mechanical characterization tests for tissue engineering applications MRS Adv. 3 1697Google Scholar
  104. 104.
    Dardano P, Caliò A, Di Palma V, Bevilacqua M F, Di Matteo A and De Stefano L 2015 A photolithographic approach to polymeric microneedles array fabrication Materials 8 5484Google Scholar
  105. 105.
    Johnson A R, Caudill C L, Tumbleston J R, Bloomquist C J, Moga K A, Ermoshkin A, Shirvanyants D, Mecham S J, Luft J C and DeSimone J M 2016 Single-step fabrication of computationally designed microneedles by continuous liquid interface production PLoS ONE 11 e0162518PubMedGoogle Scholar
  106. 106.
    Tian Z, Cheng J, Liu J and Zhu Y 2019 Dissolving graphene/poly (acrylic acid) microneedles for potential transdermal drug delivery and photothermal therapy J. Nanosci. Nanotechnol. 19 2453PubMedGoogle Scholar
  107. 107.
    Chen M-C, Ling M-H and Kusuma S J 2015 Poly-γ-glutamic acid microneedles with a supporting structure design as a potential tool for transdermal delivery of insulin Acta Biomater. 24 106PubMedGoogle Scholar
  108. 108.
    Jin J, Reese V, Coler R, Carter D and Rolandi M 2014 Chitin microneedles for an easy-to-use tuberculosis skin test Adv. Healthc. Mater. 3 349Google Scholar
  109. 109.
    Demir Y K, Akan Z and Kerimoglu O 2013 Sodium alginate microneedle arrays mediate the transdermal delivery of bovine serum albumin PLoS ONE 8 e63819PubMedPubMedCentralGoogle Scholar
  110. 110.
    Jangid K, Bhargava V and Jayakumar N 2014 A Review: conducting polymers and their applications. Res. J. Pharm. Biol. Chem. Sci. 5 383Google Scholar
  111. 111.
    Mülhaupt R 2004 Hermann Staudinger and the origin of macromolecular chemistry Angew. Chem. Int. Ed. 43 1054Google Scholar
  112. 112.
    Huang H and Fu C 2007 Different fabrication methods of out-of-plane polymer hollow needle arrays and their variations J. Micromech. Microeng. 17 393Google Scholar
  113. 113.
    Eltayib E, Brady A J, Caffarel-Salvador E, Gonzalez-Vazquez P, Alkilani A Z, McCarthy H O, McElnay J C and Donnelly R F 2016 Hydrogel-forming microneedle arrays: potential for use in minimally-invasive lithium monitoring Eur. J. Pharm. Biopharm. 102 123Google Scholar
  114. 114.
    Bhatnagar S, Bankar N G, Kulkarni M V and Venuganti V V K 2019 Dissolvable microneedle patch containing doxorubicin and docetaxel is effective in 4T1 xenografted breast cancer mouse model Int. J. Pharm. 556 263Google Scholar
  115. 115.
    Bhatnagar S, Saju A, Cheerla K D, Gade S K, Garg P and Venuganti V V K 2018 Corneal delivery of besifloxacin using rapidly dissolving polymeric microneedles Drug Deliv. Transl. Res. 8 473Google Scholar
  116. 116.
    Bhatnagar S, Kumari P, Pattarabhiran S P and Venuganti V V K 2018 Zein Microneedles for Localized Delivery of Chemotherapeutic Agents to Treat Breast Cancer: Drug Loading, Release Behavior, and Skin Permeation Studies AAPS PharmSciTech 19 1818PubMedGoogle Scholar
  117. 117.
    Park J-H, Choi S-O, Kamath R, Yoon Y-K, Allen M G and Prausnitz M R 2007 Polymer particle-based micromolding to fabricate novel microstructures Biomed. Microdev. 9 223Google Scholar
  118. 118.
    Donnelly R F, Majithiya R, Singh T R R, Morrow D I J, Garland M J, Demir Y K, Migalska K, Ryan E, Gillen D, Scott C J and Woolfson A D 2011 Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique Pharm. Res. 28 41Google Scholar
  119. 119.
    Park J-H, Allen M G and Prausnitz M R 2006 Polymer microneedles for controlled-release drug delivery Pharm. Res. 23 1008Google Scholar
  120. 120.
    Xiang Z, Wang H, Pant A, Pastorin G and Lee C 2013 Development of vertical SU-8 microtubes integrated with dissolvable tips for transdermal drug delivery Biomicrofluidics 7 026502Google Scholar
  121. 121.
    Chu L Y and Prausnitz M R 2011 Separable arrowhead microneedles J. Control Release 149 242PubMedGoogle Scholar
  122. 122.
    Fukushima K, Ise A, Morita H, Hasegawa R, Ito Y, Sugioka N and Takada K 2011 Two-layered dissolving microneedles for percutaneous delivery of peptide/protein drugs in rats Pharm. Res. 28 7Google Scholar
  123. 123.
    Chen M C, Ling M H, Wang K W, Lin Z W, Lai B H and Chen D H 2015 Near-infrared light-responsive composite microneedles for on-demand transdermal drug delivery Biomacromolecules 16 1598PubMedGoogle Scholar
  124. 124.
    Caffarel-Salvador E, Brady A J, Eltayib E, Meng T, Alonso-Vicente A, Gonzalez-Vazquez P, Torrisi B M, Vicente-Perez E M, Mooney K, Jones D S, Bell S E J, McCoy C P, McCarthy H O, McElnay J C and Donnelly R F 2016 Hydrogel-forming microneedle arrays allow detection of drugs and glucose in vivo: potential for use in diagnosis and therapeutic drug monitoring PLoS ONE 10 e0145644Google Scholar
  125. 125.
    Pettus J and Edelman S V 2017 Recommendations for using real-time continuous glucose monitoring (rtCGM) data for insulin adjustments in type 1 diabetes J. Diabetes Sci. Technol. 11 138PubMedGoogle Scholar
  126. 126.
    Hu X, Yu J, Qian C, Lu Y, Kahkoska A R, Xie Z, Jing X, Buse J B and Gu Z 2017 H2O2-responsive vesicles integrated with transcutaneous patches for glucose-mediated insulin delivery ACS Nano 11 613PubMedPubMedCentralGoogle Scholar
  127. 127.
    Yu J, Qian C, Zhang Y, Cui Z, Zhu Y, Shen Q, Ligler F S, Buse J B and Gu Z 2017 Hypoxia and H2O2 dual-sensitive vesicles for enhanced glucose-responsive insulin delivery Nano Lett. 17 733Google Scholar
  128. 128.
    Wang J, Ye Y, Yu J, Kahkoska A R, Zhang X, Wang C, Sun W, Corder R D, Chen Z and Khan S A 2018 Core–shell microneedle gel for self-regulated insulin delivery ACS Nano 12 2466PubMedPubMedCentralGoogle Scholar
  129. 129.
    Kim H-G, Gater D L and Kim Y-C 2018 Development of transdermal vitamin D3 (VD3) delivery system using combinations of PLGA nanoparticles and microneedles Drug Deliv. Transl. Res. 8 281Google Scholar
  130. 130.
    Zaric M, Lyubomska O, Touzelet O, Poux C, Al-Zahrani S, Fay F, Wallace L, Terhorst D, Malissen B and Henri S 2013 Skin dendritic cell targeting via microneedle arrays laden with antigen-encapsulated poly-D, L-lactide-co-glycolide nanoparticles induces efficient antitumor and antiviral immune responses ACS Nano 7 2042PubMedPubMedCentralGoogle Scholar
  131. 131.
    Niu L, Chu L Y, Burton S A, Hansen K J and Panyam J 2019 Intradermal delivery of vaccine nanoparticles using hollow microneedle array generates enhanced and balanced immune response J. Control Release 294 268PubMedGoogle Scholar
  132. 132.
    Lan X, She J, Lin D-a, Xu Y, Li X, Yang W-f, Lui V W Y, Jin L, Xie X and Su Y-x 2018 Microneedle-mediated delivery of lipid-coated cisplatin nanoparticles for efficient and safe cancer therapy ACS Appl. Mater. Interfaces 10 33060Google Scholar
  133. 133.
    van der Maaden K, Varypataki E M, Romeijn S, Ossendorp F, Jiskoot W and Bouwstra J 2014 Ovalbumin-coated pH-sensitive microneedle arrays effectively induce ovalbumin-specific antibody and T-cell responses in mice Eur. J. Pharm. Biopharm. 88 310Google Scholar
  134. 134.
    Duong H T T, Kim N W, Thambi T, Giang Phan V H, Lee M S, Yin Y, Jeong J H and Lee D S 2018 Microneedle arrays coated with charge reversal pH-sensitive copolymers improve antigen presenting cells-homing DNA vaccine delivery and immune responses J.Control Release 269 225PubMedGoogle Scholar
  135. 135.
    Martanto W, Moore J S, Kashlan O, Kamath R, Wang P M, O’Neal J M and Prausnitz M R 2006 Microinfusion using hollow microneedles Pharm. Res. 23 104PubMedGoogle Scholar
  136. 136.
    Ayittey P N, Walker J S, Rice J J and de Tombe P P 2008 Glass microneedles for force measurements: a finite-element analysis model Pflüg. Arch. Eur. J. Phy. 457 1415Google Scholar
  137. 137.
    Park S Y, Lee H U, Lee Y-C, Kim G H, Park E C, Han S H, Lee J G, Choi S, Heo N S, Kim D L, Huh Y S and Lee J 2014 Wound healing potential of antibacterial microneedles loaded with green tea extracts Mater. Sci. Eng. C 42 757Google Scholar
  138. 138.
    Larrañeta E, Lutton R E M, Brady A J, Vicente-Pérez E M, Woolfson A D, Thakur R R S and Donnelly R F 2015 Microwave-assisted preparation of hydrogel-forming microneedle arrays for transdermal drug delivery applications Macromol. Mater. Eng. 300 586Google Scholar
  139. 139.
    Ali A A, McCrudden C M, McCaffrey J, McBride J W, Cole G, Dunne N J, Robson T, Kissenpfennig A, Donnelly R F and McCarthy H O 2017 DNA vaccination for cervical cancer; a novel technology platform of RALA mediated gene delivery via polymeric microneedles Nanomedicine 13 921Google Scholar
  140. 140.
    Korkmaz E, Friedrich E E, Ramadan M H, Erdos G, Mathers A R, Burak Ozdoganlar O, Washburn N R and Falo L D 2015 Therapeutic intradermal delivery of tumor necrosis factor-alpha antibodies using tip-loaded dissolvable microneedle arrays Acta Biomater. 24 96PubMedGoogle Scholar
  141. 141.
    Ling M-H and Chen M-C 2013 Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats Acta Biomater. 9 8952PubMedGoogle Scholar
  142. 142.
    Watanabe T, Hagino K and Sato T 2014 Evaluation of the effect of polymeric microneedle arrays of varying geometries in combination with a high-velocity applicator on skin permeability and irritation Biomed. Microdev. 16 591Google Scholar
  143. 143.
    Lippmann J M, Geiger E J and Pisano A P 2007 Polymer investment molding: Method for fabricating hollow, microscale parts Sens. Actuators A Phys. 134 2Google Scholar
  144. 144.
    Moon S J, Lee S S, Lee H S and Kwon T H 2005 Fabrication of microneedle array using LIGA and hot embossing process Microsyst. Technol. 11 311Google Scholar
  145. 145.
    Li J, Zhou Y, Yang J, Ye R, Gao J, Ren L, Liu B, Liang L and Jiang L 2019 Fabrication of gradient porous microneedle array by modified hot embossing for transdermal drug delivery Mater. Sci. Eng. C 96 576Google Scholar
  146. 146.
    Norman J J, Choi S-O, Tong N T, Aiyar A R, Patel S R, Prausnitz M R and Allen M G 2013 Hollow microneedles for intradermal injection fabricated by sacrificial micromolding and selective electrodeposition Biomed. Microdev. 15 203Google Scholar
  147. 147.
    Park S C, Kim M J, Baek S-K, Park J-H and Choi S-O 2019 Spray-formed layered polymer microneedles for controlled biphasic drug delivery Polymers 11 369Google Scholar
  148. 148.
    Sullivan S P, Koutsonanos D G, Del Pilar Martin M, Lee J W, Zarnitsyn V, Choi S O, Murthy N, Compans R W, Skountzou I and Prausnitz M R 2010 Dissolving polymer microneedle patches for influenza vaccination Nat. Med. 16 915Google Scholar
  149. 149.
    Gittard S D, Ovsianikov A, Akar H, Chichkov B, Monteiro-Riviere N A, Stafslien S, Chisholm B, Shin C-C, Shih C-M, Lin S-J, Su Y-Y and Narayan R J 2010 Two photon polymerization-micromolding of polyethylene glycol-gentamicin sulfate microneedles Adv. Eng. Mater. 12 B77Google Scholar
  150. 150.
    Luo Z, Sun W, Fang J, Lee K, Li S, Gu Z, Dokmeci M R and Khademhosseini A 2019 Biodegradable gelatin methacryloyl microneedles for transdermal drug delivery Adv. Healthc. Mater. 8 1801054Google Scholar
  151. 151.
    Sullivan S P, Murthy N and Prausnitz M R 2008 Minimally invasive protein delivery with rapidly dissolving polymer microneedles Adv. Mater. 20 933Google Scholar
  152. 152.
    Boehm R D, Miller P R, Schell W A, Perfect J R and Narayan R J 2013 Inkjet printing of amphotericin B onto biodegradable microneedles using piezoelectric inkjet printing JOM 65 525Google Scholar
  153. 153.
    Pere C P P, Economidou S N, Lall G, Ziraud C, Boateng J S, Alexander B D, Lamprou D A and Douroumis D 2018 3D printed microneedles for insulin skin delivery Int. J. Pharm. 544 425Google Scholar
  154. 154.
    Lee K and Jung H 2012 Drawing lithography for microneedles: a review of fundamentals and biomedical applications Biomaterials 33 7309PubMedGoogle Scholar
  155. 155.
    Lee K, Lee C Y and Jung H 2011 Dissolving microneedles for transdermal drug administration prepared by stepwise controlled drawing of maltose Biomaterials 32 3134PubMedGoogle Scholar
  156. 156.
    Kochhar J S, Anbalagan P, Shelar S B, Neo J K, Iliescu C and Kang L 2014 Direct microneedle array fabrication off a photomask to deliver collagen through skin Pharm. Res. 31 1724Google Scholar
  157. 157.
    Lee J W, Choi S-O, Felner E I and Prausnitz M R 2011 Dissolving microneedle patch for transdermal delivery of human growth hormone Small 7 531PubMedPubMedCentralGoogle Scholar
  158. 158.
    Doraiswamy A, Jin C, Narayan R J, Mageswaran P, Mente P, Modi R, Auyeung R, Chrisey D B, Ovsianikov A and Chichkov B 2006 Two photon induced polymerization of organic–inorganic hybrid biomaterials for microstructured medical devices Acta Biomater. 2 267PubMedGoogle Scholar
  159. 159.
    Gittard S D, Ovsianikov A, Chichkov B N, Doraiswamy A and Narayan R J 2010 Two-photon polymerization of microneedles for transdermal drug delivery Expert Opin. Drug Deliv. 7 513Google Scholar
  160. 160.
    Thepsonthi T, Milesi N and Özel T 2012 Design and prototyping of micro-needle arrays for drug delivery using customized tool-based micro-milling process. In Proceedings of the 1st International Conference on Design and Processes for Medical Devices, at Brescia, Italy 2012Google Scholar
  161. 161.
    Zhou W, Ling W-s, Liu W, Peng Y and Peng J 2015 Laser direct micromilling of copper-based bioelectrode with surface microstructure array Opt. Lasers Eng. 73 7Google Scholar
  162. 162.
    Arai M, Nishinaka Y and Miki N 2015 Electroencephalogram measurement using polymer-based dry microneedle electrode Jpn. J. Appl. Phys. 54 06FP14Google Scholar
  163. 163.
    Martanto W, Davis S P, Holiday N R, Wang J, Gill H S and Prausnitz M R 2004 Transdermal delivery of insulin using microneedles in vivo Pharm. Res. 21 947Google Scholar
  164. 164.
    Kim J D, Kim M, Yang H, Lee K and Jung H 2013 Droplet-born air blowing: novel dissolving microneedle fabrication J. Control Release 170 430PubMedGoogle Scholar
  165. 165.
    Lee J W, Han M-R and Park J-H 2013 Polymer microneedles for transdermal drug delivery J. Drug Target. 21 211PubMedGoogle Scholar
  166. 166.
    Shikida M, Sato K, Tokoro K and Uchikawa D 2000 Differences in anisotropic etching properties of KOH and TMAH solutions Sens. Actuators A Phys. 80 179Google Scholar
  167. 167.
    Lutton R E M, Larrañeta E, Kearney M-C, Boyd P, Woolfson A D and Donnelly R F 2015 A novel scalable manufacturing process for the production of hydrogel-forming microneedle arrays Int. J. Pharm. 494 417Google Scholar
  168. 168.
    Trautmann A, Heuck F, Mueller C, Ruther P and Paul O 2005 (Eds.) Replication of microneedle arrays using vacuum casting and hot embossing. In The 13 th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. Transducers ‘05; 2005 5–9 June, Seoul, South KoreaGoogle Scholar
  169. 169.
    Information from http://www.raphas.com/rnd/dab-technique/?ckattempt=1. Accessed on 13 March 2019
  170. 170.
    Boehm R D, Miller P R, Daniels J, Stafslien S and Narayan R J 2014 Inkjet printing for pharmaceutical applications Mater. Today 17 247Google Scholar
  171. 171.
    Uddin M J, Scoutaris N, Klepetsanis P, Chowdhry B, Prausnitz M R and Douroumis D 2015 Inkjet printing of transdermal microneedles for the delivery of anticancer agents Int. J. Pharm. 494 593Google Scholar
  172. 172.
    Ross S, Scoutaris N, Lamprou D, Mallinson D and Douroumis D 2015 Inkjet printing of insulin microneedles for transdermal delivery Drug Deliv. Transl. Res. 5 451Google Scholar
  173. 173.
    Allen E A, O’Mahony C, Cronin M, O’Mahony T, Moore A C and Crean A M 2016 Dissolvable microneedle fabrication using piezoelectric dispensing technology Int. J. Pharm. 500 1Google Scholar
  174. 174.
    Gittard S D, Miller P R, Jin C, Martin T N, Boehm R D, Chisholm B J, Stafslien S J, Daniels J W, Cilz N, Monteiro-Riviere N A, Nasir A and Narayan R J 2011 Deposition of antimicrobial coatings on microstereolithography-fabricated microneedles JOM 63 59Google Scholar
  175. 175.
    Economidou S N, Lamprou D A and Douroumis D 2018 3D printing applications for transdermal drug delivery Int. J. Pharm. 544 415Google Scholar
  176. 176.
    Vallet-Regí M, Colilla M, Izquierdo-Barba I and Manzano M 2017 Mesoporous silica nanoparticles for drug delivery: current insights Molecules 23 47PubMedCentralGoogle Scholar
  177. 177.
    Pradeep Narayanan S and Raghavan S 2018 Fabrication and characterization of gold-coated solid silicon microneedles with improved biocompatibility Int. J. Adv. Manuf. Technol.  https://doi.org/10.1007/s00170-018-2596-3 CrossRefGoogle Scholar
  178. 178.
    Manam N, Harun W, Shri D, Ghani S, Kurniawan T, Ismail M H and Ibrahim M 2017 Study of corrosion in biocompatible metals for implants: A review J. Alloys Compd. 701 698Google Scholar
  179. 179.
    Hayashi K, Matsuguchi N, Uenoyama K and Sugioka Y 1992 Re-evaluation of the biocompatibility of bioinert ceramics in vivo Biomaterials 13 195PubMedGoogle Scholar
  180. 180.
    Chevalier J and Gremillard L 2009 Ceramics for medical applications: a picture for the next 20 years J. Eur. Ceram. Soc. 29 1245Google Scholar
  181. 181.
    Duheyne P, Beight J, Cuckler J, Evans B and Radin S 1990 Effect of calcium phosphate coating characteristics on early post-operative bone tissue ingrowth Biomaterials 11 531Google Scholar
  182. 182.
    Ducheyne P and Qiu Q 1999 Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function Biomaterials 20 2287PubMedGoogle Scholar
  183. 183.
    Ovsianikov A, Chichkov B, Mente P, Monteiro-Riviere N A, Doraiswamy A and Narayan R J 2007 Two photon polymerization of polymer–ceramic hybrid materials for transdermal drug delivery Int. J. Appl. Ceram. Technol. 4 22Google Scholar
  184. 184.
    Markovsky E, Baabur-Cohen H, Eldar-Boock A, Omer L, Tiram G, Ferber S, Ofek P, Polyak D, Scomparin A and Satchi-Fainaro R 2012 Administration, distribution, metabolism and elimination of polymer therapeutics J. Control Release 161 446PubMedGoogle Scholar
  185. 185.
    Sato T, Ishii T and Okahata Y 2001 In vitro gene delivery mediated by chitosan. Effect of pH, serum, and molecular mass of chitosan on the transfection efficiency Biomaterials 22 2075PubMedGoogle Scholar
  186. 186.
    D’Ayala G, Malinconico M and Laurienzo P 2008 Marine derived polysaccharides for biomedical applications: chemical modification approaches Molecules 13 2069PubMedGoogle Scholar
  187. 187.
    Aduba D C and Yang H 2017 Polysaccharide fabrication platforms and biocompatibility assessment as candidate wound dressing materials Bioengineering (Basel) 4 1Google Scholar
  188. 188.
    Liu S, Jin M-n, Quan Y-s, Kamiyama F, Katsumi H, Sakane T and Yamamoto A 2012 The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin J. Control Release 161 933PubMedGoogle Scholar
  189. 189.
    Kogan G, Šoltés L, Stern R, Schiller J and Mendichi R 2008 In: Hyaluronic acid: its function and degradation in in vivo systems Studies in Natural Products Chemistry Atta-ur-Rahman (Ed.) Vol. 34 (Amsterdam: Elsevier) p. 789Google Scholar
  190. 190.
    Lynn A K, Yannas I V and Bonfield W 2004 Antigenicity and immunogenicity of collagen J. Biomed. Mater. Res. B Appl. Biomater. 71B 343Google Scholar
  191. 191.
    El-Rashidy A A, Waly G, Gad A, Roether J A, Hum J, Yang Y, Detsch R, Hashem A A, Sami I and Goldmann W H 2018 Antibacterial activity and biocompatibility of zein scaffolds containing silver-doped bioactive glass Biomed. Mater. 13 065006Google Scholar
  192. 192.
    Dong J, Sun Q and Wang J-Y 2004 Basic study of corn protein, zein, as a biomaterial in tissue engineering, surface morphology and biocompatibility Biomaterials 25 4691PubMedGoogle Scholar
  193. 193.
    Voskerician G, Shive M S, Shawgo R S, Von Recum H, Anderson J M, Cima M J and Langer R 2003 Biocompatibility and biofouling of MEMS drug delivery devices Biomaterials 24 1959PubMedGoogle Scholar
  194. 194.
    Cho S-H, Lu H M, Cauller L, Romero-Ortega M I, Lee J-B and Hughes G A 2008 Biocompatible SU-8-based microprobes for recording neural spike signals from regenerated peripheral nerve fibers IEEE Sens. J. 8 1830Google Scholar
  195. 195.
    Rezwan K, Chen Q, Blaker J and Boccaccini A R 2006 Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering Biomaterials 27 3413PubMedGoogle Scholar
  196. 196.
    Brown A, Zaky S, Ray Jr H and Sfeir C 2015 Porous magnesium/PLGA composite scaffolds for enhanced bone regeneration following tooth extraction Acta Biomater. 11 543PubMedGoogle Scholar
  197. 197.
    Ye Y, Yu J, Wen D, Kahkoska A R and Gu Z 2018 Polymeric microneedles for transdermal protein delivery Adv. Drug Deliv. Rev. 127 106Google Scholar
  198. 198.
    Böstman O 1991 Absorbable implants for the fixation of fractures JBJS 73 148Google Scholar
  199. 199.
    Böstman O and Pihlajamäki H 2000 Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation: a review Biomaterials 21 2615PubMedGoogle Scholar
  200. 200.
    Xu C, Inai R, Kotaki M and Ramakrishna S 2004 Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering Biomaterials 25 877PubMedGoogle Scholar
  201. 201.
    Chen M-C, Chan H-A, Ling M-H and Su L-C 2017 Implantable polymeric microneedles with phototriggerable properties as a patient-controlled transdermal analgesia system J. Mater. Chem. B 5 496Google Scholar
  202. 202.
    Pitt C, Chasalow F, Hibionada Y, Klimas D and Schindler A 1981 Aliphatic polyesters. I. The degradation of poly (ϵ-caprolactone) in vivo J. Appl. Polym. Sci. 26 3779Google Scholar
  203. 203.
    Pitt C and Schindler A 1984 Capronor–a biodegradable delivery system for levonorgestrelGoogle Scholar
  204. 204.
    Ali U, Karim K J B A and Buang N A 2015 A review of the properties and applications of poly (methyl methacrylate)(PMMA) Polym. Rev. 55 678Google Scholar
  205. 205.
    Miyagawa S, Sato T and Iguchi T Subchapter 101C-Bisphenol A In: Y Takei, H Ando, K Tsutsui 2016 (Eds.) Handbook of Hormones (San Diego: Academic Press) p. 577Google Scholar
  206. 206.
    Salman H H and Azcarate I G 2014 Nanoparticles comprising esters of poly (methyl vinyl ether-co-maleic anhydride) and uses thereof. Google PatentsGoogle Scholar
  207. 207.
    Camacho A I, Da Costa Martins R, Tamayo I, de Souza J, Lasarte J J, Mansilla C, Esparza I, Irache J M and Gamazo C 2011 Poly(methyl vinyl ether-co-maleic anhydride) nanoparticles as innate immune system activators Vaccine 29 7130Google Scholar
  208. 208.
    Caló E, Barros J, Ballamy L and Khutoryanskiy V V 2016 Poly (vinyl alcohol)–Gantrez® AN cryogels for wound care applications RSC Adv. 6 105487Google Scholar
  209. 209.
    Paradossi G, Cavalieri F, Chiessi E, Spagnoli C and Cowman M K 2003 Poly (vinyl alcohol) as versatile biomaterial for potential biomedical applications J. Mater. Sci. Mater. Med. 14 687PubMedGoogle Scholar
  210. 210.
    Hyon S-H, Cha W-I, Ikada Y, Kita M, Ogura Y and Honda Y 1994 Poly (vinyl alcohol) hydrogels as soft contact lens material J. Biomater. Sci. Polym. Ed. 5 397PubMedGoogle Scholar
  211. 211.
    Noguchi T, Yamamuro T, Oka M, Kumar P, Kotoura Y, Hyonyt S H and Ikadat Y 1991 Poly (vinyl alcohol) hydrogel as an artificial articular cartilage: evaluation of biocompatibility J. Appl. Biomater. 2 101PubMedGoogle Scholar
  212. 212.
    Liu X, Xu Y, Wu Z and Chen H 2013 Poly(N-vinylpyrrolidone)-modified surfaces for biomedical applications Macromol. Biosci. 13 147Google Scholar
  213. 213.
    Robinson B V, Sullivan F M, Borzelleca J F and Schwartz S L 1990 PVP: A Critical Review of the Kinetics and Toxicology of Polyvinylpyrrolidone (Povidone) (Michigan: Lewis Publishers)Google Scholar
  214. 214.
    Saxena A, Mozumdar S and Johri A K 2006 Ultra-low sized cross-linked polyvinylpyrrolidone nanoparticles as non-viral vectors for in vivo gene delivery Biomaterials 27 5596PubMedGoogle Scholar
  215. 215.
    McCrudden M T C, Alkilani A Z, Courtenay A J, McCrudden C M, McCloskey B, Walker C, Alshraiedeh N, Lutton R E M, Gilmore B F, Woolfson A D and Donnelly R F 2015 Considerations in the sterile manufacture of polymeric microneedle arrays Drug Deliv. Transl. Res. 5 3Google Scholar
  216. 216.
    Kim S, Lee J, Shayan F L, Kim S, Huh I, Ma Y, Yang H, Kang G and Jung H 2018 Physicochemical study of ascorbic acid 2-glucoside loaded hyaluronic acid dissolving microneedles irradiated by electron beam and gamma ray Carbohydr. Polym. 180 297Google Scholar
  217. 217.
    Prausnitz M R 2017 Engineering microneedle patches for vaccination and drug delivery to skin Annu. Rev. Chem. Biomol. Eng. 8 177Google Scholar
  218. 218.
    García L E G, MacGregor M N, Visalakshan R M, Ninan N, Cavallaro A A, Trinidad A D, Zhao Y, Hayball A J D and Vasilev K 2019 Self-sterilizing antibacterial silver-loaded microneedles Chem. Commun. 55 171Google Scholar

Copyright information

© Indian Academy of Sciences 2019

Authors and Affiliations

  1. 1.Department of PharmacyBirla Institute of Technology and Science (BITS) Pilani, Hyderabad CampusHyderabadIndia

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