Novel series of acridone-1,2,3-triazole derivatives: microwave-assisted synthesis, DFT study and antibacterial activities

  • Mohammed Aarjane
  • Siham Slassi
  • Bouchra Tazi
  • Mohamed Maouloua
  • Amina AmineEmail author
Regular Article


A series of novel acridones bearing a 1,2,3-triazole unit have been synthesized and characterized. The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) was performed using both a conventional method and a microwave-assisted synthetic method. The in vitro antibacterial potencies of all the synthesized compounds were determined against five clinically isolated strains: Escherichia coli, Klebsiella pneumonia, Pseudomonas putida, Serratia marcescens and Staphyloccocus aureus. Furthermore, DFT quantum chemical calculations were carried out to investigate geometry structures, frontier molecular orbital and gap energies, and molecular electrostatic potential maps (MEP). Lipophilicities of the studied compounds were also determined.

Graphic abstract

Novel acridone-1,2,3-triazole derivatives were synthesized using both a conventional and a microwave-assisted synthetic method. The antibacterial potencies of the compounds are reported. DFT quantum chemical calculations were carried out to investigate geometry structures, frontier molecular orbital and gap energies, and molecular electro static potential maps (MEP). Lipophilicities were also determined.


Acridone 1, 2, 3-triazole microwave DFT study antibacterial activitiy 


Supplementary material

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Supplementary material 1 (pdf 1533 KB)


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Copyright information

© Indian Academy of Sciences 2019

Authors and Affiliations

  1. 1.LCBAE, CMMBA, Faculty of ScienceUniversity Moulay IsmailZitoune, MeknesMorocco
  2. 2.Département des Sciences de BaseEcole Nationale d’AgricultureMeknesMorocco
  3. 3.Medical Microbiology LaboratoryMohamed V. HospitalMeknesMorocco

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