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Silicon-containing diorganotin complexes with salicylaldehyde thiosemicarbazone and their anticancer activity

  • Qian Liu
  • Bo Xie
  • Sen LinEmail author
  • Qihua Liao
  • Ruihong Deng
  • Yan ZhaohuaEmail author
Regular Article
  • 36 Downloads

Abstract

Eight novel silicon-containing diorganotin complexes with salicylaldehyde thiosemicarbazone were synthesized. They were characterized by \(^{1}\hbox {H NMR}\), \(^{13}\hbox {C NMR}\), IR spectra, elemental analysis and X-ray single-crystal diffraction. Spectroscopic and X-rays studies indicated that the thiosemicarbazone Schiff base and tin atom were coordinated as a parallel five- and six-membered heterocyclic structure. In addition, the bioassay of the synthesized complexes was performed and the results show that the silicon-containing diorganotin complexes with salicylaldehyde thiosemicarbazone have good anticancer activity on human breast cancer cells.

Graphic Abstract

Eight silicon-containing organotin complexes containing salicylaldehyde thiosemicarbazone derivatives were synthesized. The Sn atom in the complexes were penta-coordinated in a distorted trigonal bipyramidal configuration, forming a five- and six-membered chelate ring through the coordination of oxygen, nitrogen, sulfur atoms. All the complexes showed significant anticancer activity, especially complex 3cb and 3ab.

Keywords

Diorganotin synthesis structure anticancer activity 

Notes

Supplementary material

12039_2019_1650_MOESM1_ESM.pdf (451 kb)
Supplementary material 1 (pdf 451 KB)

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Copyright information

© Indian Academy of Sciences 2019

Authors and Affiliations

  1. 1.Department of ChemistryNanchang UniversityNanchangPeople’s Republic of China

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