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Cytotoxic effects of coumarin substituted benzimidazolium salts against human prostate and ovarian cancer cells

  • Mert Olgun KarataşEmail author
  • Suat Tekin
  • Bülent Alici
  • Süleyman Sandal
Regular Article
  • 72 Downloads

Abstract

Coumarin and benzimidazole derivatives have individual biological activities including anticancer. In this study, we aimed to synthesize coumarin-benzimidazole hybrids in order to investigate their anticancer properties. For this purpose, six 6-substituted-4-chloromethylene coumarin derivatives were synthesized. Sixteen coumarin substituted benzimidazolium chlorides were synthesized by the reaction of 4-chloromethylene coumarin and N-benzylbenzimidazole derivatives. All of the synthesized compounds were characterized by \(^{1}\hbox {H}\) and \(^{13}\hbox {C}\) NMR, IR spectroscopic techniques and elemental analyses. Cytotoxicities of all compounds were tested by [3-(4,5-dimethylthiazole)-2-yl]-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay against human prostate (PC-3) and ovarian (A2780) cancer cells. All compounds performed significant cytotoxicities at \(100\,\upmu \hbox {M}\) against both cancer cell lines. Moreover, some compounds performed significant activities at \(1\,\upmu \hbox {M}\) against both cancer cell lines and the obtained results suggest that this type of compounds are promising candidates for the treatment of human prostate and ovarian cancers.

Graphic abstract

Six 4-chloromethylenecoumarin derivatives and sixteen coumarin substituted benzimidazolium chlorides were synthesized and characterized. Cytotoxic properties of all compounds were tested against human prostate and ovarian cancer cell lines.

Keywords

Benzimidazole benzimidazolium salt coumarin cytotoxicity 

Notes

Acknowledgements

The authors report no conflicts of interest. The authors are alone responsible for the content and writing of the paper.

Supplementary material

12039_2019_1647_MOESM1_ESM.pdf (1.4 mb)
Supplementary material 1 (pdf 1392 KB)

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Copyright information

© Indian Academy of Sciences 2019

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of Scienceİnönü UniversityMalatyaTurkey
  2. 2.Department of Physiology, Faculty of Medicineİnönü UniversityMalatyaTurkey

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