A sequential one-pot tandem approach for the synthesis of 4-tosyl-5-aryloxazoles from carboxylic acids
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An efficient method for the synthesis of 4-tosyl-5-aryloxazoles directly from aromatic carboxylic acids has been reported. The method involves the conversion of aromatic carboxylic acids to tosyl carboxylates by treating with tosyl chloride in the presence of potassium carbonate and its subsequent reaction with tosylmethyl isocyanide in the presence of sodium hydride to get 4-tosyl-5-aryloxazoles.
KeywordsOxazole tosylmethylisocyanide tandem cyclization one-pot
MPS thanks UGC-SAP DRS III (Grant No. UGC F-540/10/DRS-III (SAP-I) Dated 14-09-2016). Authors are grateful to Institution of Excellence, University of Mysore, Mysuru for spectral analysis. N. Rajeev thanks UGC, New Delhi for providing RGNF.
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- 29.CCDC 1833176 contains the supplementary crystallographic data for this paper. The data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/getstructures