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Journal of Biosciences

, 44:106 | Cite as

Deconstructing age reprogramming

  • Prim B SinghEmail author
  • Petr P Laktionov
  • Andrew G Newman
Mini-Review
  • 18 Downloads

Abstract

It has been proposed that age reprogramming enables old cells to be rejuvenated without passage through an embryonic stage (Singh and Zacouto in J Biosci 35:315–319, 2010). As such, age reprogramming stands apart from the induced pluripotent stem (iPS) and nuclear transfer-embryonic stem (NT-ES) cell therapies where histo-compatible cells are produced only after passage through an embryonic stage. It avoids many of the disadvantages associated with iPS and NT-ES cell therapies. Experimental evidence in support of age reprogramming is burgeoning. Here, we discuss possible new approaches to enhance age reprogramming, which will have considerable benefits for regenerative therapies.

Keywords

Age reprogramming Epigenetic rejuvenation iPS cells reprogramming factors Epigenetic clock eAge 

Notes

Acknowledgements

This work was supported by a grant from the Ministry of Education and Science of Russian Federation #14.Y26.31.0024 and Nazarbayev University (Grant No. 090118FD5311).

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Copyright information

© Indian Academy of Sciences 2019

Authors and Affiliations

  1. 1.Nazarbayev University School of MedicineAstanaKazakhstan
  2. 2.Epigenetics Laboratory, Department of Natural SciencesNovosibirsk State UniversityNovosibirskRussian Federation
  3. 3.Institute of Cell and NeurobiologyCharité – Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of HealthBerlinGermany

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