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Multifaceted role of keratins in epithelial cell differentiation and transformation

  • Crismita Dmello
  • Saumya S Srivastava
  • Richa Tiwari
  • Pratik R Chaudhari
  • Sharada Sawant
  • Milind M VaidyaEmail author
Review
  • 18 Downloads

Abstract

Keratins, the epithelial-predominant members of the intermediate filament superfamily, are expressed in a pairwise, tissue-specific and differentiation-dependent manner. There are 28 type I and 26 type II keratins, which share a common structure comprising a central coiled coil α-helical rod domain flanked by two nonhelical head and tail domains. These domains harbor sites for major posttranslational modifications like phosphorylation and glycosylation, which govern keratin function and dynamics. Apart from providing structural support, keratins regulate various signaling machinery involved in cell growth, motility, apoptosis etc. However, tissue-specific functions of keratins in relation to cell proliferation and differentiation are still emerging. Altered keratin expression pattern during and after malignant transformation is reported to modulate different signaling pathways involved in tumor progression in a context-dependent fashion. The current review focuses on the literature related to the role of keratins in the regulation of cell proliferation, differentiation and transformation in different types of epithelia.

Keywords

Cell proliferation differentiation keratins posttranslational modification squamous cell carcinoma transformation 

Notes

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Copyright information

© Indian Academy of Sciences 2019

Authors and Affiliations

  1. 1.Vaidya LaboratoryAdvanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC)Kharghar, Navi MumbaiIndia
  2. 2.Homi Bhabha National InstituteMumbaiIndia

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