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Journal of Biosciences

, 44:21 | Cite as

Overview of genomics and post-genomics research on type 2 diabetes mellitus: Future perspectives and a framework for further studies

  • Battini Mohan ReddyEmail author
  • Rayabarapu Pranavchand
  • S A A Latheef
Review
  • 113 Downloads

Abstract

In this review, we briefly outlined salient features of pathophysiology and results of the genetic association studies hitherto conducted on type 2 diabetes. Primarily focusing on the current status of genomic research, we briefly discussed the limited progress made during the post-genomic era and tried to identify the limitations of the post-genomic research strategies. We suggested reanalysis of the existing genomic data through advanced statistical and computational methods and recommended integrated genomics-metabolomics approaches for future studies to facilitate understanding of the gene-environment interactions in the manifestation of the disease. We also propose a framework for research that may be apt for determining the effects of urbanization and changing lifestyles in the manifestation of complex genetic disorders like type 2 diabetes in the Indian populations and offset the confounding effects of both genetic and environmental factors in the natural way.

Keywords

Complex genetic disorders genomics Indian scenario metabolomics proteomics transcriptomics type 2 diabetes mellitus 

Notes

References

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Copyright information

© Indian Academy of Sciences 2019

Authors and Affiliations

  • Battini Mohan Reddy
    • 1
    Email author
  • Rayabarapu Pranavchand
    • 1
  • S A A Latheef
    • 1
  1. 1.Department of GeneticsOsmania UniversityHyderabadIndia

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