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Journal of Biosciences

, Volume 32, Issue 1, pp 169–180 | Cite as

Integrative content-driven concepts for bioinformatics “beyond the cell”

  • Edgar WingenderEmail author
  • Torsten Crass
  • Jennifer D Hogan
  • Alexander E Kel
  • Olga V Kel-Margoulis
  • Anatolij P Potapov
Article

Abstract

Bioinformatics has delivered great contributions to genome and genomics research, without which the world-wide success of this and other global (‘omics’) approaches would not have been possible. More recently, it has developed further towards the analysis of different kinds of networks thus laying the foundation for comprehensive description, analysis and manipulation of whole living systems in modern “systems biology”. The next step which is necessary for developing a systems biology that deals with systemic phenomena is to expand the existing and develop new methodologies that are appropriate to characterize intercellular processes and interactions without omitting the causal underlying molecular mechanisms. Modelling the processes on the different levels of complexity involved requires a comprehensive integration of information on gene regulatory events, signal transduction pathways, protein interaction and metabolic networks as well as cellular functions in the respective tissues / organs.

Keywords

Bioinformatics gene regulation networks intercellular networks signal transduction pathways systems biology 

Abbreviations used

BC

Betweenness centrality

CES

composite elements

CMA

composite module analyser

PTMS

posttranslational modifications

ST

signal, transduction

TFs

transcription factors

TFBS

transcription factor binding sites

TSSs

transcription start sites

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Copyright information

© Indian Academy of Sciences 2007

Authors and Affiliations

  • Edgar Wingender
    • 1
    • 2
    Email author
  • Torsten Crass
    • 2
  • Jennifer D Hogan
    • 3
  • Alexander E Kel
    • 1
  • Olga V Kel-Margoulis
    • 1
  • Anatolij P Potapov
    • 2
  1. 1.BIOBASE GmbHWolfenbüttelGermany
  2. 2.Department of BioinformaticsUKG/University of GöttingenGöttingenGermany
  3. 3.BIOBASE Corp.BeverlyUSA

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