Current Understanding of the Role of Neuronal Calcium Sensor 1 in Neurological Disorders

  • Julia Bandura
  • Zhong-Ping FengEmail author


Neuronal calcium sensor 1 (NCS-1) is a high-affinity calcium-binding protein and its ubiquitous expression in the nervous system implies a wide range of functions. To date, it has been implicated in regulation of calcium channels in both axonal growth cones and presynaptic terminals, pre- and postsynaptic plasticity mechanisms, learning and memory behaviors, dopaminergic signaling, and axonal regeneration. This review summarizes these functions and relates them to several diseases in which NCS-1 plays a role, such as schizophrenia and bipolar disorder, X-linked mental retardation and fragile X syndrome, and spinal cord injury. Many questions remain unanswered about the role of NCS-1 in these diseases, particularly as the genetic factors that control NCS-1 expression in both normal and diseased states are still poorly understood. The review further identifies the therapeutic potential of manipulating the interaction of NCS-1 with its many targets and suggests directions for future research on the role of NCS-1 in these disorders.


NCS-1 Frequenin Calcium-binding proteins Schizophrenia Bipolar disorder X-linked mental retardation 



Molecular graphics and analyses were performed with UCSF Chimera, developed by the Resource for Biocomputing, Visualization, and Informatics at the University of California, San Francisco, with support from NIH P41-GM103311. JB is a recipient of an Ontatio Graduate Scholarship (OGS). This work is funded by a Canadian Institutes of Health Research (CIHR) Project Grant to Z.P.F. (CIHR-PJT-153155).


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Physiology, Faculty of MedicineUniversity of TorontoTorontoCanada

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