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Association Between PARP1 Single Nucleotide Polymorphism and Brain Tumors

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Abstract

To systematically evaluate the association between poly(ADP-ribose) polymerase 1 (PARP1) rs1136410 T>C and brain tumor risk, a meta-analysis has been carried out. We performed a meta-analysis of 2004 brain tumor patients and 2944 controls by use of STATA version 12.0 to determine whether the risk of brain tumors was associated with the genotypes or alleles of rs1136410 T>C. We found a significantly decreased risk (ranging from 0.18- to 0.16-fold) in the dominant model (OR = 0.84, 95 % CI = 0.75–0.95), the C vs. T model (OR = 0.82, 95 % CI = 0.74–0.91), and the CT vs. TT model (OR = 0.86, 95 % CI = 0.76–0.98). The same genetic models demonstrated noteworthy associations when analysis was restrained to glioma (OR = 0.85, 95 % CI = 0.75–0.96; OR = 0.83, 95 % CI = 0.74–0.92; OR = 0.87, 95 % CI = 0.76–0.99, respectively). This meta-analysis suggests that PARP1 rs1136410 T>C may play a significant role in the protection against the development of brain tumors and glioma.

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Authors and Affiliations

  1. Department of Lung Cancer, 307 Hospital of PLA, Affiliated Hospital of Academy of Military Medical Sciences, Fengtai Area, Beijing, China

    Hong Wang, Kun Zhang, Haifeng Qin, Lin Yang, Liyu Zhang & Yanyan Cao

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  1. Hong Wang
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  2. Kun Zhang
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  3. Haifeng Qin
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  4. Lin Yang
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  5. Liyu Zhang
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  6. Yanyan Cao
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Correspondence to Hong Wang.

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Wang, H., Zhang, K., Qin, H. et al. Association Between PARP1 Single Nucleotide Polymorphism and Brain Tumors. Mol Neurobiol 53, 2083–2089 (2016). https://doi.org/10.1007/s12035-015-9168-4

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