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Ion recognition and fluorescent imaging of conjugated polymer fluorescent probes for Fe(III)

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Novel polymer fluorescent probes for Fe(III) were synthesized to achieve a steady combination of ferric ions. In the Schiff base reaction of probes’ synthetic process, o-, m- and p-phenylenediamine were respectively introduced to result in a series of new conjugated polymer fluorescent probes. Analyses on optical properties of the probes and probe-Fe(III) characteristic recognition through FS showed an application of the conjugated probes in quantitative identification and detection of Fe(III) with quick responses. Fluorescent imaging of the probes and probe-Fe(III) in living cells in vitro revealed low toxicity of the probes and predicted the probes’ further application for instant \(\text {Fe}^{{3+}}\) detection in clinical diagnosis and dynamic tracing of \(\text {Fe}^{{3+}}\) in biological systems.

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  1. 1.

    Bolognin S, Messori L and Zatta P 2009 Neuromol. Med. 11 223

  2. 2.

    Hill J M 1988 The distribution of iron in the brain (USA: Taylor and Francis)

  3. 3.

    Barnham K J and Bush A I 2008 Curr. Opin. Chem. Biol. 12 222

  4. 4.

    Zecca L, Youdim M B H, Riederer P, Connor J R and Crichton R R 2004 Nat. Rev. Neurosci. 5 863

  5. 5.

    Arnold G L, Weyer S and Anbar A D 2004 Anal. Chem. 76 322

  6. 6.

    McRae R, Bagchi P, Sumalekshmy S and Fahrni C J 2009 Chem. Rev. 109 4780

  7. 7.

    Bourassa M W and Miller L M 2012 Metallomics 4 721

  8. 8.

    Lee M H, Kim J S and Sessler J L 2015 Chem. Soc. Rev.44 4185

  9. 9.

    Carter K P, Young A M and Palmer A E 2014 Chem. Rev. 114 4564

  10. 10.

    Huang W, Zhou P, Yan W B, He C, Xiong L Q, Li F Y et al 2009 Environ. Monit. Assess. 11 330

  11. 11.

    Zhou Y, Chu K H, Zhen H F, Fang Y and Yao C 2013 Spectrochim. Acta: Part A 106 197

  12. 12.

    Lin W Y, Cao X W, Ding Y D, Yuan L and Yu Q X 2010 Org. Biomol. Chem. 8 3618

  13. 13.

    Chen X Q, Nam S W, Jou M J, Kim Y, Kim S J, Park S et al 2008 Org. Lett. 10 5235

  14. 14.

    Lakowicz J R 2006 Principles of fluorescence spectroscopy (USA: Springer)

  15. 15.

    Thompson R B 2006 Fluorescence sensors and biosensors (USA: Taylor and Francis)

  16. 16.

    Goncalves M S T 2009 Chem. Rev. 109 190

  17. 17.

    Xiang Y and Tong A J 2006 Org. Lett.8 1549

  18. 18.

    Sun Y, Liu Y L and Wei G 2009 Sens. Actuators B143 171

  19. 19.

    Bourson J, Pouget J and Valeur B 1993 J. Phys. Chem. 97 4552

  20. 20.

    Zhou J, Yu X, Jin X, Tang G, Zhang W, Hu J et al 2014 J. Mol. Struct. 1058 14

  21. 21.

    Cai Z-B, Liu L-F and Zhou M 2013 Opt. Mater. 35 1481

  22. 22.

    Seçkin T, Sezer S and Köytepe S 2018 J. Inorg. Organomet. Polym. Mater. 28 2825

  23. 23.

    Varadaraju C, Paulraj M S, Tamilselvan G, Muthu Vijayan Enoch I V, Srinivasadesikan V and Shyi-Long L 2019 J. Incl. Phenom. Macro. 95 79

  24. 24.

    Gong T, Yang W, Zhang M, Zhou W and Xue R 2018 J. Mater. Sci.53 13900

  25. 25.

    Bhattacharyya B, Kundu A, Guchhait N and Dhara K 2017 J. Fluoresc.27 1041

  26. 26.

    Breuer W, Epsztejn S, Millgram P and Cabantchik I Z 1995 Am. J. Physiol. 268 C1354

  27. 27.

    Zhang M, Gao Y H, Li M Y, Yu M X, Li F Y, Li L et al 2007 Tetrahedron Lett. 48 3709

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This project was supported by Xi’an Medical University Research Fund (2017GJFY04, 2018PT67), Shaanxi Natural Science Basic Research Project (2017JQ8042, 2019JQ-068) and National Natural Science Foundation of China (81702955).

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Correspondence to Zhao Cheng.

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Zheng, L., Cheng, Z., HE, H. et al. Ion recognition and fluorescent imaging of conjugated polymer fluorescent probes for Fe(III). Bull Mater Sci 43, 69 (2020). https://doi.org/10.1007/s12034-019-2029-4

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  • Polymer probes
  • Fe(III) recognition
  • quantitative detection
  • fluorescent imaging