A novel injectable composite hydrogel based on chitosan and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) reinforced with nanohydroxyapatite particles was synthesized. The chemical structure and morphology of the composite hydrogel were characterized. The composite hydrogel porosity, swelling, mechanical properties, viscoelasticity and in vitro biodegradation were also examined. Compared with the non-reinforced hydrogel, the composite hydrogel showed increased compressive strength, elastic modulus, viscous modulus, stiffness and had shear-thinning behaviour proving the injectability of the system. Swelling and biodegradation studies revealed that the composite scaffold possesses proper hydrophilicity and biodegradability. These properties make this composite hydrogel a promising injectable scaffold for bone regeneration.
Injectable hydrogel chitosan poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanohydroxyapatite viscoelasticity bone regeneration
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We acknowledge Sherif Kandil and Labiba El-Khordagui at Alexandria University, Egypt as well as El-Refaie Kenawy at Tanta University, Egypt, for their scientific guidance and moral support throughout the work.
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