Medical Oncology

, 36:98 | Cite as

Small cell carcinoma of the bladder: the characteristics of molecular alterations, treatment, and follow-up

  • Yanling Wang
  • Qijun Li
  • Jing Wang
  • Mengting Tong
  • Haibo Xing
  • Yanan Xue
  • Hongming Pan
  • Changxing Huang
  • Da LiEmail author
Review Article


Small cell carcinoma of the bladder (SCCB) is a rare disease associated with high invasiveness and mortality. Histologically, SCCB is difficult to distinguish from small cell lung cancer (SCLC); however, it shares more similar molecular alterations with urothelial carcinoma (UC). As a result, now, the widely accepted theory about the cells of origin is that SCCB and UC probably have a common clone origin. Even the former probably comes from a preexisting UC. At present, given its rarity, early diagnoses, treatments, and follow-ups are not well established, which are vital to patients with SCCB. Inspirationally, in recent years, with the development of molecular diagnostic methods, molecular alterations of SCCB have been understood partially, which are propitious to excavate new potential therapeutic strategies and establish sound follow-ups. Therefore, the future will be light for patients with SCCB.


Small cell carcinoma of the bladder Urothelial carcinoma Small cell lung cancer Molecular alterations Treatment Follow-up 



The National Natural Science Foundation of China (No. 81573003) and Zhejiang Province Natural Science Foundation and Zhejiang Society of Mathematical Medicine Joint Foundation (No. LSY19H160005).

Compliance with ethical standards

Conflict of interests

The authors have declared that no competing interest exists.


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Authors and Affiliations

  1. 1.Department of Medical Oncology, Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouChina
  2. 2.Second Department of Medical OncologyThe Fourth Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina
  3. 3.Deparment of ICU, Xiasha Campus, Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouChina
  4. 4.Department of Medical OncologyAffiliated Hospital of Hangzhou Normal UniversityHangzhouChina

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