Advertisement

Medical Oncology

, 36:38 | Cite as

Correction to: Hesperetin induces the apoptosis of hepatocellular carcinoma cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species, ATP and calcium

  • Jixiang Zhang
  • Jia Song
  • Dandan Wu
  • Jing Wang
  • Weiguo DongEmail author
Correction
  • 151 Downloads

Correction to: Med Oncol (2015) 32:101  https://doi.org/10.1007/s12032-015-0516-z

The original version of this article unfortunately contained a mistake. During final figure preparation and manuscript submission, the similar graphs (Fig. 6c) in different papers were accidentally switched. It was subsequently noted in a further review that Fig. 2a does not match with the hesperetin concentration. The corrected figures and graphs are herein (Figs. 2a, 6c). This correction does not affect the results or conclusions of the original paper.

Fig. 2

HepG-2 cells were incubated with hesperetin, H2O2 (1 mM) pretreated + hesperetin and NAC (5 mM) pretreated + hesperetin. Apoptosis was detected after 24 h using Hoechst33258, and apoptotic features were assessed by observing chromatin condensation and fragments staining. a HepG-2 cells were incubated with hesperetin (0, 125, 250 and 500 µM); b HepG-2 cells were incubated with hesperetin (250 µM), H2O2 (1 mM) pretreated + Hesperetin(250 µM) and NAC (5 mM) pretreated + hesperetin(250 µM). Scale bar represents 50 µm. Original magnification: ×200. *P < 0.05 versus control; #P < 0.05 versus hesperetin (250 µM)

Fig. 6

In vivo antitumor effect of Hesperetin in Hepatocellular carcinoma xenograft mouse model. a Each time point represents the mean tumor volume for each group. b Tumor weight was obtained at the end of the experiment. Error bars represent the standard error of the mean (SEM). c Detection of apoptotic cells in tumor tissue by TUNEL assay. Scale bar represents 50 μm. Original magnification: 200×. *P < 0.05 versus control

Notes

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Jixiang Zhang
    • 1
  • Jia Song
    • 2
  • Dandan Wu
    • 1
  • Jing Wang
    • 1
  • Weiguo Dong
    • 1
    Email author
  1. 1.Department of GastroenterologyRenmin Hospital of Wuhan UniversityWuhanChina
  2. 2.Xinjiang Tumor HospitalXinjiang Medical UniversityÜrümqiChina

Personalised recommendations