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Medical Oncology

, 36:7 | Cite as

Postoperative weight loss followed by radical cystectomy predicts poor prognosis in patients with muscle-invasive bladder cancer

  • Kazutaka Okita
  • Shingo HatakeyamaEmail author
  • Naoki Fujita
  • Sakae Konishi
  • Hayato Yamamoto
  • Atsushi Imai
  • Takahiro Yoneyama
  • Yasuhiro Hashimoto
  • Hiroyuki Ito
  • Kazuaki Yoshikawa
  • Takuya Koie
  • Chikara Ohyama
Original Paper
  • 51 Downloads

Abstract

We aimed to investigate the impact of postoperative weight loss following radical cystectomy (RC) on patients’ prognoses. RC and urinary diversion were performed in 512 consecutive patients with muscle-invasive bladder cancer at our hospitals between May 1996 and July 2018. Demographic clinical information, pre- and postoperative serum albumin, hemoglobin, and weight were evaluated retrospectively at 1 month. We also evaluated the association of weight loss with complications and overall survival (OS) as estimated using the Kaplan–Meier method and compared using the log-rank test. Risk factors for poor OS were determined by Inverse Probability of Treatment Weighted (IPTW)-adjusted Cox regression analysis. In 385 patients who met the study search criteria, median postoperative weight loss from baseline at 1 week and 1 month was 1.1 (− 1.8%) and 3.2 (− 5.4%) kg, respectively. Patients with significant weight loss (defined as ≥ 7.5% at 1 month) had higher-grade complications within 1 month and had significantly shorter OS than those with weight loss of < 7.5%. Type of urinary diversion, loss of serum albumin, and loss of hemoglobin were not significantly associated with weight loss. IPTW-adjusted Cox regression analysis showed that such significant weight loss was an independent risk factor for poor OS. Weight loss followed by radical cystectomy was significantly associated with poor prognosis in patients with muscle-invasive bladder cancer.

Keywords

Cystectomy Weight loss Frailty Survival Bladder cancer 

Notes

Acknowledgements

The authors would like to thank Teppei Okamoto, Teppei Matsumoto, Osamu Soma, Itsuto Hamano, Hiromichi Iwamura, Takuma Narita, Yuki Fujita, Yukie Nishizawa, and Satomi Sakamoto for their invaluable support with data collection. The authors would also like to thank Enago (http://www.enago.jp) for English language review.

Funding

This work was supported by a Grant-in-Aid for Scientific Research (Grant Nos. 15H02563, 15K15579, 17K11118, 17K11119, 17K16768, 17K16770, 17K16771, 18K16681, 18K16682, 18K16717, 18K16718, 18K16719, and 18K09157) from the Japan Society for the Promotion of Science.

Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Kazutaka Okita
    • 1
  • Shingo Hatakeyama
    • 1
    Email author
  • Naoki Fujita
    • 1
  • Sakae Konishi
    • 1
  • Hayato Yamamoto
    • 1
  • Atsushi Imai
    • 1
  • Takahiro Yoneyama
    • 1
  • Yasuhiro Hashimoto
    • 1
  • Hiroyuki Ito
    • 2
  • Kazuaki Yoshikawa
    • 3
  • Takuya Koie
    • 4
  • Chikara Ohyama
    • 1
  1. 1.Department of UrologyHirosaki University Graduate School of MedicineHirosakiJapan
  2. 2.Department of UrologyAomori Rosai HospitalHachinoheJapan
  3. 3.Department of UrologyMutsu General HospitalMutsuJapan
  4. 4.Department of UrologyGifu University Graduate School of MedicineHirosakiJapan

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