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Associations Between Two Single-Nucleotide Polymorphisms in NINJ2 Gene and Risk of Psychiatric Disorders

Abstract

NINJ2 encodes a transmembrane protein that contributes in neurodevelopment and regeneration of neurons. Single-nucleotide polymorphisms (SNPs) within this gene have been associated with Alzheimer’s disease, ischemic stroke, and multiple sclerosis. The rs11833579 and rs3809263 SNPs have been associated with risk of ischemic stroke in Iranian population. While the NINJ2 rs12425791 has been with risk of ischemic stroke in East Asian population, the rs11833579 has not been associated with this condition either in East Asian population or Chinese Han population. In the current project, we genotyped rs11833579 and rs3809263 in a large cohort of neuropsychiatric patients including major depressive disorder, bipolar disorder, schizophrenia, and methamphetamine addiction. No significant difference was detected in frequencies of alleles, genotypes, or haplotypes between patients and controls. Thus, the current investigation failed to show association between rs11833579 and rs3809263 and the mentioned neuropsychiatric disorders. Future studies are needed to verify our results.

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Funding

The current study was supported by a grant from Shahid Beheshti University of Medical Sciences.

Author information

Correspondence to Mir Davood Omrani or Mohammad Taheri.

Ethics declarations

The study protocol was approved by the ethics committees of Shahid Beheshti Universities of Medical Sciences.

Conflict of Interest

The authors declare they have no conflict of interest.

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Sayad, A., Ghafouri-Fard, S., Omrani, M.D. et al. Associations Between Two Single-Nucleotide Polymorphisms in NINJ2 Gene and Risk of Psychiatric Disorders. J Mol Neurosci 70, 236–245 (2020). https://doi.org/10.1007/s12031-019-01462-1

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Keywords

  • NINJ2
  • rs11833579
  • rs3809263
  • Substance abuse
  • Bipolar disorder
  • Major depressive disorder
  • Schizophrenia