Journal of Molecular Neuroscience

, Volume 67, Issue 2, pp 276–281 | Cite as

Aberrant Expression of Long Non-coding RNAs in Peripheral Blood of Autistic Patients

  • Arezou Sayad
  • Mir Davood Omrani
  • Hamid Fallah
  • Mohammad TaheriEmail author
  • Soudeh Ghafouri-FardEmail author


Long non-coding RNAs (lncRNAs) constitute a large proportion of human transcriptome and are involved in fundamental aspects of neurodevelopment. In the present study, we evaluated expression levels of three lncRNAs, namely, Nuclear Paraspeckle Assembly Transcript 1 (NEAT1), p21-associated ncRNA DNA damage–activated (PANDA), and taurine-upregulated gene 1 (TUG1), in peripheral blood of autism spectrum disorder (ASD) patients compared with those in healthy subjects. We found a significant upregulation of NEAT1 and TUG1 in ASD patients. In addition, relative expressions of the pairs of lncRNAs were significantly correlated in both patients and healthy subjects. However, expressions of these lncRNAs were not correlated with age of study participants. The present study provides further evidences for dysregulation of lncRNAs in ASD patients.


Autism spectrum disorder NEAT1 PANDA TUG1 lncRNA 


Funding Information

The current study was supported by a grant from Shahid Beheshti University of Medical Sciences.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Medical GeneticsShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Urogenital Stem Cell Research CenterShahid Beheshti University of Medical SciencesTehranIran
  3. 3.Student Research CommitteeShahid Beheshti University of Medical SciencesTehranIran

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