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Amyloid Beta 1–42 Alters the Expression of miRNAs in Cortical Neurons

  • Erdinç Dursun
  • Esin Candaş
  • Selma Yılmazer
  • Duygu Gezen-Ak
Article

Abstract

Recently, Aβ1–42 was demonstrated to have the potential to translocate into the nucleus and to be involved in the transcriptional regulation of certain neurodegeneration-related genes. This data raises the question of whether Aβ-induced neurodegeneration might include the expression of miRNAs. Thus, our aim in this study was to investigate the effects of Aβ1–42 on certain miRNAs which are related with vitamin D metabolism, neuronal differentiation, development, and memory. This question was investigated in primary cortical neurons that were treated with 10 μM Aβ and/or 10–8 M 1,25-dihydroxyvitamin D3 at different time points by expression analysis of let-7a-5p, miR-26b-5p, miR-27b-3p, miR-31a-5p, miR-125b-5p, and miR-192-5p with qRT-PCR. Our data indicate that amyloid pathology has effects on the expression of miRNAs. Furthermore, some of these miRNAs simultaneously regulate the proteins or the enzymes involved in neuronal metabolism. The experimental setup that we used and the data we acquired supply valuable information about the miRNAs that play a part in the Aβ pathology and suggested Aβ as a counterpart of vitamin D at the crossroads of neuronal differentiation, development, and memory.

Keywords

Alzheimer’s disease Aβ Vitamin D Vitamin D receptor (VDR) miRNA 

Notes

Author Contributions

Conceived and designed the experiments: DGA and ED. Performed the experiments: DGA, ED, EC. Analyzed the data: DGA and ED. Drafted and revised the manuscript: DGA, SY, and ED. All authors reviewed the manuscript.

Funding Information

The present work was supported by the Research Fund of Istanbul University, Project no: 21585, and by the Scientific and Technological Research Council of Turkey-TUBITAK, Project no. 214S585.

Compliance with Ethical Standards

The study was approved by the Animal Welfare and Ethics Committee of Istanbul University with the numbers 26.07.2012/101, and procedures that involved experimentation on animal subjects were carried out in accordance with both the guide of Istanbul University and with the National Research Council’s guide for the care and use of laboratory animals.

Conflict of Interest

The authors declare that they have no conflict of interest.

Language Editing

The English of the manuscript has been edited by ELSEVIER Language Editing Service with the Reference Number: LE222898.

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Authors and Affiliations

  1. 1.Brain and Neurodegenerative Disorders Research Laboratory, Department of Medical Biology, Cerrahpasa Faculty of MedicineIstanbul University-CerrahpasaIstanbulTurkey
  2. 2.Department of Medical Biology, Faculty of MedicineAltinbas UniversityIstanbulTurkey

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