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Pretreatment Esophageal Wall Thickness Associated with Response to Chemoradiotherapy in Locally Advanced Esophageal Cancer

  • Kraipop Wongwaiyut
  • Sakchai Ruangsin
  • Supparerk Laohawiriyakamol
  • Siriporn Leelakiatpaiboon
  • Duangjai Sangthawan
  • Patrapim Sunpaweravong
  • Somkiat SunpaweravongEmail author
Original Research
  • 19 Downloads

Abstract

Purpose

A multimodality approach using concurrent chemoradiotherapy (CRT) followed by esophagectomy has been the standard treatment in patients with locally advanced esophageal squamous cell carcinoma (ESCC). Computed tomography (CT) is widely utilized to evaluate esophageal cancer before and after CRT. This study evaluated the utility of pretreatment maximal esophageal wall thickness on CT scans to predict treatment outcomes after CRT in patients with locally advanced ESCC.

Methods

Eighty-one patients with T3 locally advanced ESCC, whom were treated completely with CRT with and without surgery, and had available CT scans before and after CRT at a university hospital between 2005 and 2015, were retrospectively reviewed.

Result

Twenty patients (24.7%) had esophagectomy after neoadjuvant CRT and sixty-one patients (75.3%) had definitive CRT. The maximal esophageal wall thicknesses were measured retrospectively and correlated with the response and survival after treatment. A total of 40% of neoadjuvant CRT patients achieved a pCR. There was a significant difference in pretreatment maximal esophageal wall thickness between the pCR and non-pCR groups (mean 11.9 ± 5.3 mm versus 16.9 ± 3 mm; p = 0.01). Pretreatment maximal esophageal wall thickness < 10 mm was significantly related to better overall survival than ≥ 10 mm (median survival 79 months versus 15 months; HR 3.21, 95%CI 1.14–9; p = 0.02). The neoadjuvant CRT group had significantly better survival than the definitive CRT group (median survival 51 months versus 14.5 months; HR 0.46; 95%CI 0.25–0.85; p = 0.01).

Conclusion

In our study, pretreatment esophageal wall thickness of T3 locally advanced ESCC is a useful indicator for predicting survival and pCR after treatment.

Keywords

Chemoradiotherapy Computed tomography (CT) Esophageal cancer Esophagectomy Wall thickness 

Notes

Acknowledgments

We would like to thank David Patterson of the Faculty of Medicine Office of International Relations for his assistance with the English in the manuscript, and Jureerat Saengthong of the Research Unit for helping with statistical analysis in the study.

Funding information

This study was supported by the Faculty of Medicine, Prince of Songkla University.

Compliance with Ethical Standards

This retrospective study was approved by Institutional Ethical Commission Review Board.

Conflict of interests

The author(s) declare no potential conflicts of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Kraipop Wongwaiyut
    • 1
  • Sakchai Ruangsin
    • 1
  • Supparerk Laohawiriyakamol
    • 1
  • Siriporn Leelakiatpaiboon
    • 2
  • Duangjai Sangthawan
    • 2
  • Patrapim Sunpaweravong
    • 3
  • Somkiat Sunpaweravong
    • 1
    Email author
  1. 1.Department of Surgery, Faculty of MedicinePrince of Songkla UniversitySongklaThailand
  2. 2.Department of Radiology, Faculty of MedicinePrince of Songkla UniversitySongklaThailand
  3. 3.Department of Internal Medicine, Faculty of MedicinePrince of Songkla UniversitySongklaThailand

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