Advertisement

Journal of Gastrointestinal Cancer

, Volume 50, Issue 1, pp 175–180 | Cite as

Music Is Capable of Inducing Changes in Gene Expression in Gastric Cancer Cells

  • Sebastián Ramírez-Rivera
  • Giuliano BernalEmail author
Brief Communication

Abstract

Purpose

Music has recognized beneficial effects on cancer patients; however, very little is known about the molecular processes which produce these benefits. The aim of this work was to evaluate the effect of music on proliferation and gene expression in gastric cancer cells.

Methods

AGS gastric cancer cells were exposed to metal and classical music, and subsequently cell proliferation and expression of genes associated with apoptosis and cell-cycle control were evaluated.

Results

Proliferation of AGS cells increased when exposed to metal music, but not when exposed to classical music. Gene expression of caspase-3 and 8 and cyclin B1 increased in response to both musical genres; classical music repressed the expression of p53, and metal music repressed the expression of PUMA.

Conclusions

This is the first study to demonstrate music as a modulator of gene expression in a cancer cell line. Additional experiments are required to better understand the mechanisms of how different musical genres can induce changes in gene expression.

Keywords

Gastric cancer Music Apoptosis Gene expression 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Lestard N dos R, Valente RC, Lopes A, Capella MAM. Direct effects of music in non-auditory cells in culture. Noise Health. 2013;15(66):307.CrossRefGoogle Scholar
  2. 2.
    Bro ML, Jespersen KV, Hansen JB, Vuust P, Abildgaard N, Gram J, et al. Kind of blue: a systematic review and meta-analysis of music interventions in cancer treatment. Psychooncology. 2018;27(2):386–400.CrossRefGoogle Scholar
  3. 3.
    Bradt J, Dileo C, Magill L, Teague A. Music interventions for improving psychological and physical outcomes in cancer patients. Cochrane Database Syst Rev. 2016;15(8):CD006911.Google Scholar
  4. 4.
    Bieligmeyer S, Helmert E, Hautzinger M, Vagedes J. Feeling the sound - short-term effect of a vibroacoustic music intervention on well-being and subjectively assessed warmth distribution in cancer patients-A randomized controlled trial. Complement Ther Med. 2018;40:171–8.CrossRefGoogle Scholar
  5. 5.
    Fukui H, Toyoshima K. Music increase altruism through regulating the secretion of steroid hormones and peptides. Med Hypotheses. 2014;83(6):706–8.CrossRefGoogle Scholar
  6. 6.
    Fancourt D, Williamon A, Carvalho L, Steptoe A, Dow R, Lewis I. Singing modulates mood, stress, cortisol, cytokine and neuropeptide activity in cancer patients and carers. Ecancermedicalscience. 2016;10:631.CrossRefGoogle Scholar
  7. 7.
    Lestard N dos R, Capella MAM. Exposure to music alters cell viability and cell motility of human nonauditory cells in culture. Evid Based Complement Alternat Med. 2016;2016:1–7.CrossRefGoogle Scholar
  8. 8.
    Jones H, Feth L, Rumpf D, Hefti A, Mariotti A. Acoustic energy affects human gingival fibroblast proliferation but leaves protein production unchanged. J Clin Periodontol. 2000;27(11):832–8.CrossRefGoogle Scholar
  9. 9.
    Kirste I, Nicola Z, Kronenberg G, Walker TL, Liu RC, Kempermann G. Is silence golden? Effects of auditory stimuli and their absence on adult hippocampal neurogenesis. Brain Struct Funct. 2015;220(2):1221–8.CrossRefGoogle Scholar
  10. 10.
    Lee H, Saini N, Parris AB, Zhao M, Yang X. Ganetespib induces G2/M cell cycle arrest and apoptosis in gastric cancer cells through targeting of receptor tyrosine kinase signaling. Int J Oncol. 2017;51(3):967–74.Google Scholar
  11. 11.
    Xu YX, Wang B, Zhao XH. In vitro effects and the related molecular mechanism of galangin and quercetin on human gastric cancer cell line (SGC-7901). Pak J Pharm Sci. 2017;30(4):1279–87.Google Scholar
  12. 12.
    Kong G-M, Tao W-H, Diao Y-L, Fang P-H, Wang J-J, Bo P, et al. Melittin induces human gastric cancer cell apoptosis via activation of mitochondrial pathway. World J Gastroenterol. 2016;22(11):3186–95.CrossRefGoogle Scholar
  13. 13.
    Sui C-G, Meng F-D, Li Y, Jiang Y. Antiproliferative activity of rosamultic acid is associated with induction of apoptosis, cell cycle arrest, inhibition of cell migration and caspase activation in human gastric cancer (SGC-7901) cells. Phytomedicine. 2015;22(9):796–806.CrossRefGoogle Scholar
  14. 14.
    Shalini S, Dorstyn L, Dawar S, Kumar S. Old, new and emerging functions of caspases. Cell Death Differ. 2015;22(4):526–39.CrossRefGoogle Scholar
  15. 15.
    Huang K-H, Fang W-L, Li AF-Y, Liang P-H, Wu C-W, Shyr Y-M, et al. Caspase-3, a key apoptotic protein, as a prognostic marker in gastric cancer after curative surgery. Int J Surg. 2018;52:258–63.CrossRefGoogle Scholar
  16. 16.
    Yasuda M, Takesue F, Inutsuka S, Honda M, Nozoe T, Korenaga D. Overexpression of cyclin B1 in gastric cancer and its clinicopathological significance: an immunohistological study. J Cancer Res Clin Oncol. 2002;128(8):412–6.CrossRefGoogle Scholar
  17. 17.
    Hikisz P, Kiliańska Z. Puma, a critical mediator of cell death — one decade on from its discovery. Cell Mol Biol Lett. 2012;17(4):646–69.CrossRefGoogle Scholar
  18. 18.
    Yu J, Zhang L. PUMA, a potent killer with or without p53. Oncogene. 2008;27(Suppl 1):71–83.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Laboratory of Molecular and Cellular Biology of Cancer, Department of Biomedical Sciences, Faculty of MedicineUniversidad Católica del NorteCoquimboChile

Personalised recommendations