Underlying Colorectal Cancer Was Rarely Detected After an Episode of Acute Diverticulitis: a Retrospective Analysis of 225 Patients

  • Tawfik KhouryEmail author
  • Mahmud Mahamid
  • Ahmad Lubany
  • Mohammad Safadi
  • Amir Farah
  • Wisam Sbeit
  • Amir Mari
Original Research



The aim of the present study was to determine the prevalence of underlying colorectal carcinoma (CRC) in a cohort of patients who experienced an episode of acute diverticulitis and to assess clinical and laboratory parameters that suggest CRC diagnosis.


We performed a single center retrospective study in EMMS Nazareth Hospital from April 2014 to April 2018. All Patients who experienced an episode of acute diverticulitis and underwent a colonoscopy up to 6-month period were included in the study.


Two hundred twenty-five patients (225) patients were included. The mean age was 55.73 ± 13.81 (24–93). One hundred thirty-nine (139) patients were males. Underlying CRC was diagnosed in 2 out of 225 (0.89%) patients and colonic polyps were found in 17 out of 225 patients (7.56%). The average time interval between the episode of diverticulitis and the performance of colonoscopy was 6 weeks. Male gender was significantly associated with CRC and polyp findings (P = 0.039). Moreover, platelet count (353,000 vs. 234,000, P = 0.002) and platelet to lymphocyte ratio (223.65 vs. 127.4, P = 0.015) showed statistically significant correlation with CRC as compared to colonic polyps.


The rate of underlying CRC diagnosis was extremely low after an episode of acute diverticulitis. Male gender and platelet to lymphocyte ratio were predictors for the presence of underlying CRC.


Diverticulitis Colon Cancer Rate 



colorectal cancer


computed tomography


International Statistical Classification of Diseases


white blood cells




standard deviation




Compliance with Ethical Standards

The study was approved by the local institutional ethic committee. Written informed consent was waived due to the retrospective non-interventional study design.

Conflict of Interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Tawfik Khoury
    • 1
    • 2
    • 3
    Email author
  • Mahmud Mahamid
    • 1
    • 2
  • Ahmad Lubany
    • 4
  • Mohammad Safadi
    • 4
  • Amir Farah
    • 4
  • Wisam Sbeit
    • 3
  • Amir Mari
    • 1
    • 2
  1. 1.Gastroenterology and endoscopy unitedThe Nazareth Hospital, EMMSNazarethIsrael
  2. 2.Faculty of medicineBar-Ilan UniversityRamat GanIsrael
  3. 3.Galilee Medical Center, Bar Ilan Faculty of MedicineInstitute of Gastroenterology and Liver DiseasesNahariaIsrael
  4. 4.Department of surgeryThe Nazareth hospital, EMMSNazarethIsrael

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