Alpha-fetoprotein Secreting Neuroendocrine Carcinoma of the Liver: a Case Report and Literature Review
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Neuroendocrine tumors (NETs) occur in organs and tissues that contain peptides and amine-producing cells with different hormonal profiles depending on the region in which they are originated [1, 2]. NETs mostly occur in the gastrointestinal and bronchopulmonary system, and they are mostly seen in rectum, jejunum/ileum, and pancreas in gastrointestinal system . Hepatic neuroendocrine tumors are rarely seen, and low-grade carcinoid tumors constitute the majority of cases . On the other hand, hepatic neuroendocrine carcinomas (hNECs) are high-grade tumors that are rarely observed .
Alpha-fetoprotein (AFP) is a glycoprotein secreted by the liver and fetal yolk sac during the gestational period . Except for malign diseases such as hepatocellular carcinoma (HCC) and yolk sac tumors, AFP level increases during benign diseases such as chronic liver disease, viral hepatitis, and cirrhosis. Despite published reports showing increased AFP levels in patients with NET,...
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The authors declare that they have no conflict of interest.
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- 4.Maggard MA, O’Connell JB, Ko CY. Updated population based review of carcinoid tumors. Ann Surg 2004; 240: 117–22.Google Scholar
- 7.Shah T, Srirajaskanthan R, Bhogal M, Toubanakis C, Meyer T, Noonan A, et al. Alpha-fetoprotein and human chorionic gonadotrophin-beta as prognostic markers in neuroendocrine tumour patients. Br J Cancer 2008; 99(1):72–77.Google Scholar
- 10.Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO classification of tumours of the digestive system. Geneve: World Health Organization; 2010.Google Scholar