Journal of Gastrointestinal Cancer

, Volume 50, Issue 1, pp 170–174 | Cite as

Therapeutic Challenges in the Management of Bleeding Duodenal Gastrointestinal Stromal Tumor: a Case Report and Review of Literature

  • Gautham Krishnamurthy
  • Harjeet SinghEmail author
  • Vishal Sharma
  • Ajay Savlania
  • Rakesh Kumar Vasishta
Mgmt. of Complex Cases in GI Oncology



Duodenum is an uncommon site for the gastrointestinal stromal tumors (GISTs). Though the principles of management are the same of that elsewhere in the gastrointestinal tract, the anatomical complexity poses challenges in deciding the most appropriate treatment. A bleeding GIST further compounds the difficulty in managing such patients.

Case Report

A twenty-eight-year-old female presented with bleeding duodenal lesion secondary to mucosal ulceration. Imaging confirmed large heterogeneous lesion arising from the second part of duodenum. Surgery was planned in view of persistent blood transfusion requirement. Pancreaticoduodenectomy was done and the patient had an uneventful postoperative period.


Review of literature of duodenal GIST especially regarding the tough decisions that have to be made in the diagnosis and management of bleeding lesions has been done.


The availability of various options in addressing bleeding duodenal GIST should make the surgeon choose the best modality for the patient weighing the pros and cons of each modality.


Gastrointestinal stromal tumor Duodenum Imatinib Pancreaticoduodenectomy Bleeding 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Informed Consent

Was obtained from the patient regarding the usage of his information for the purpose of publication.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of General SurgeryPost Graduate Institute of Medical Education and ResearchChandigarhIndia
  2. 2.GastroenterologyPost Graduate Institute of Medical Education and ResearchChandigarhIndia
  3. 3.Department of PathologyPost Graduate Institute of Medical Education and ResearchChandigarhIndia

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