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Extranodal Marginal Zone B Cell (MALT) Lymphoma of the Esophagus

  • James H. Tabibian
  • Amir Kalani
  • Anna M. Moran
  • Kashyap PanganamamulaEmail author
Case Report

Introduction

Approximately, one-quarter of all non-Hodgkin’s lymphoma cases manifest extranodally, half of which are located in the gastrointestinal tract. The majority of the cases are mature B cell neoplasms which arise in the stomach and are highly associated with H. pylori infection [1]. In contrast, primary esophageal lymphoma is exceedingly rare, with only 18 cases reported to date in the world literature, nearly all of which are from Eastern Asia [2, 3]. Moreover, primary esophageal lymphoma does not have a clear association with H. pylori. Due to the rare occurrence of esophageal mucosa-associated lymphoid tissue (MALT) lymphoma, there is a paucity of data regarding clinical findings, endoscopic features, treatment regimen, and overall prognosis.

Case Report

A 72-year-old non-Hispanic White woman with well-controlled gastroesophageal reflux underwent esophagogastroduodenoscopy (EGD) for new-onset anemia. This revealed a 2 cm long, raised, longitudinally indentated, soft,...

Notes

Author Contributions

AK assisted with the manuscript preparation and editing. JHT drafted the manuscript and organized images. AMM provided histopathology data and images and edited the manuscript. KP edited the manuscript and provided the endoscopic and radiographic images and is the article guarantor.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Informed Consent

Informed consent was obtained for publication of the case details.

References

  1. 1.
    Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, et al. The World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. Report of the clinical advisory committee meeting, Airlie house, Virginia, November, 1997. Ann Oncol. 1999;10(12):1419–32.CrossRefGoogle Scholar
  2. 2.
    Okerbloom JA, Armitage JO, Zetterman R, Linder J. Esophageal involvement by non-Hodgkin’s lymphoma. Am J Med. 1984;77(2):359–61.CrossRefGoogle Scholar
  3. 3.
    Ma Q, Zhang C, Fang S, Zhong P, Zhu X, Lin L, et al. Primary esophageal mucosa-associated lymphoid tissue lymphoma: a case report and review of literature. Medicine (Baltimore). 2017;96(13):e6478.CrossRefGoogle Scholar
  4. 4.
    Tarui T, Ishikawa N, Kadoya S, Watanabe G. Co-occurrence of papillary thyroid cancer and MALT lymphoma of the thyroid with severe airway obstruction: a case report and review of the literature. Int J Surg Case Rep. 2014;5(9):594–7.CrossRefGoogle Scholar
  5. 5.
    Weissferdt A, Moran CA. Primary MALT-type lymphoma of the thymus: a clinicopathological and immunohistochemical study of six cases. Lung. 2011;189(6):461–6.CrossRefGoogle Scholar
  6. 6.
    Gezen C, Kement M, Oncel M, Tuncay E, Sahlepci T, Alkan S. Mucosa associated lymphoid tissue lymphoma of the colon: a case report. Cases J. 2009;2:9316.CrossRefGoogle Scholar
  7. 7.
    Terada T. CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung. Diagn Pathol. 2012;7:16.CrossRefGoogle Scholar
  8. 8.
    Delli FS, Zaraboukas T, Mandekou-Lefaki I. Primary MALT type skin lymphoma-is ‘Wait and See’ a possible strategy? Clin Med Oncol. 2008;2:153–8.Google Scholar
  9. 9.
    Toso A, Aluffi P, Capello D, Conconi A, Gaidano G, Pia F. Clinical and molecular features of mucosa-associated lymphoid tissue (MALT) lymphomas of salivary glands. Head Neck. 2009;31(9):1181–7.CrossRefGoogle Scholar
  10. 10.
    Sagaert X, Van Cutsem E, De Hertogh G, Geboes K, Tousseyn T. Gastric MALT lymphoma: a model of chronic inflammation-induced tumor development. Nat Rev Gastroenterol Hepatol. 2010;7(6):336–46.CrossRefGoogle Scholar
  11. 11.
    Hu C, Yi C, Dai X. Clinical study of 31 patients with primary gastric mucosa-associated lymphoid tissue lymphoma. J Gastroenterol Hepatol. 2006;21(4):722–6.CrossRefGoogle Scholar
  12. 12.
    Kishi K, Maeda H, Nakamura Y, Shirai S, Sato M. Radiotherapy for mucosa-associated lymphoid tissue (MALT) lymphoma of the esophagus: a case report with a diagnostic and therapeutic discussion. Int J Clin Oncol. 2012;17(2):174–80.CrossRefGoogle Scholar

Copyright information

© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019

Authors and Affiliations

  • James H. Tabibian
    • 1
    • 2
  • Amir Kalani
    • 3
  • Anna M. Moran
    • 4
  • Kashyap Panganamamula
    • 2
    • 5
    Email author
  1. 1.Division of Gastroenterology, Department of MedicineOlive View-UCLA Medical CenterSylmarUSA
  2. 2.Division of GastroenterologyUniversity of PennsylvaniaPhiladelphiaUSA
  3. 3.The Vatche and Tamar Manoukian Division of Digestive Diseases, Department of MedicineDavid Geffen School of Medicine at UCLALos AngelesUSA
  4. 4.Department of Pathology and Laboratory MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  5. 5.Penn Presbyterian Medical CenterPhiladelphiaUSA

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