Extranodal Marginal Zone B Cell (MALT) Lymphoma of the Esophagus

  • James H. Tabibian
  • Amir Kalani
  • Anna M. Moran
  • Kashyap PanganamamulaEmail author
Case Report


Approximately, one-quarter of all non-Hodgkin’s lymphoma cases manifest extranodally, half of which are located in the gastrointestinal tract. The majority of the cases are mature B cell neoplasms which arise in the stomach and are highly associated with H. pylori infection [1]. In contrast, primary esophageal lymphoma is exceedingly rare, with only 18 cases reported to date in the world literature, nearly all of which are from Eastern Asia [2, 3]. Moreover, primary esophageal lymphoma does not have a clear association with H. pylori. Due to the rare occurrence of esophageal mucosa-associated lymphoid tissue (MALT) lymphoma, there is a paucity of data regarding clinical findings, endoscopic features, treatment regimen, and overall prognosis.

Case Report

A 72-year-old non-Hispanic White woman with well-controlled gastroesophageal reflux underwent esophagogastroduodenoscopy (EGD) for new-onset anemia. This revealed a 2 cm long, raised, longitudinally indentated, soft,...


Author Contributions

AK assisted with the manuscript preparation and editing. JHT drafted the manuscript and organized images. AMM provided histopathology data and images and edited the manuscript. KP edited the manuscript and provided the endoscopic and radiographic images and is the article guarantor.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Informed Consent

Informed consent was obtained for publication of the case details.


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Copyright information

© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019

Authors and Affiliations

  • James H. Tabibian
    • 1
    • 2
  • Amir Kalani
    • 3
  • Anna M. Moran
    • 4
  • Kashyap Panganamamula
    • 2
    • 5
    Email author
  1. 1.Division of Gastroenterology, Department of MedicineOlive View-UCLA Medical CenterSylmarUSA
  2. 2.Division of GastroenterologyUniversity of PennsylvaniaPhiladelphiaUSA
  3. 3.The Vatche and Tamar Manoukian Division of Digestive Diseases, Department of MedicineDavid Geffen School of Medicine at UCLALos AngelesUSA
  4. 4.Department of Pathology and Laboratory MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  5. 5.Penn Presbyterian Medical CenterPhiladelphiaUSA

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