Journal of Gastrointestinal Cancer

, Volume 50, Issue 1, pp 134–136 | Cite as

Acinar Cell Carcinoma of Pancreas: a Case Report and Review of Literature

  • Hemanth Makineni
  • Ramakrishnan Ayloor SeshadriEmail author
  • Shirley Sundersingh
Case Report


Acinar cells are the predominant cells of the pancreas but malignant transformation is rare with acinar cell carcinoma (ACC) accounting for 1–2% of all pancreatic neoplasms in adults and about 15% in the paediatric population [1]. Although grouped under exocrine neoplasms of the pancreas, ACCs have distinct clinical, morphological and pathological characteristics [2]. We report a case of ACC of pancreas in a 57-year-old gentleman who presented with a lesion in the tail of pancreas with liver metastasis. The management and brief review of literature is presented.

Case Report

A 57-year-old gentleman presented with epigastric pain of 1 month duration. Physical examination did not reveal any significant findings. Serum amylase and lipase were within normal limits. CT scan of the abdomen and pelvis showed a large irregular heterogeneous mass measuring 10.2 × 8.2 cm, with early enhancement and rapid wash out arising from the tail of the pancreas, encasing the splenic vessels and...


Compliance with Ethical Standards


No funding received.

Conflict of Interest

The authors declare that they have no conflict of interest.


  1. 1.
    Klimstra DS. Nonductal neoplasms of the pancreas. Mod Pathol. 2007;20:S94–112.CrossRefGoogle Scholar
  2. 2.
    La Rosa S, Sessa F, Capella C. Acinar cell carcinoma of the pancreas: overview of clinicopathologic features and insights into molecular pathology. Front Med (Lausanne). 2015;2:41.Google Scholar
  3. 3.
    Chen J, Baithun SI. Morphological study of 391 cases of exocrine pancreatic tumors with special reference to the classification of exocrine pancreatic carcinoma. J Pathol. 1985;146:17–29.CrossRefGoogle Scholar
  4. 4.
    Tian L, Lv XF, Dong J, Zhou J, Zhang Y, Xi SY, et al. Clinical features and CT/MRI findings of pancreatic acinar cell carcinoma. Int J Clin Exp Med. 2015;8:14846–54.Google Scholar
  5. 5.
    Holen KD, Klimstra DS, Hummer A, et al. Clinical characteristics and outcomes from an institutional series of acinar cell carcinoma of the pancreas and related tumors. J Clin Oncol. 2002;20:4673–8. 12CrossRefGoogle Scholar
  6. 6.
    Ambrosini-Spaltro A, Potí O, De Palma M, Filotico M. Pancreatictype acinar cell carcinoma of the stomach beneath a focus of pancreatic metaplasia of the gastric mucosa. Hum Pathol. 2009;40:746–9.CrossRefGoogle Scholar
  7. 7.
    Kitagami H, Kondo S, Hirano S, Kawakami H, Egawa S, Tanaka M. Acinar cell carcinoma of the pancreas: clinical analysis of 115 patients from Pancreatic Cancer Registry of Japan Pancreas Society. Pancreas. 2007;35:42–6.CrossRefGoogle Scholar
  8. 8.
    Hruban RH, Pitman MB, Klimstra DS. AFIP atlas of tumor pathology series 4 fascicle 6: tumors of the pancreas. Washington, DC: American Registry of Pathology; 2007.Google Scholar
  9. 9.
    Stelow EB, Shaco-Levy R, Bao F, Garcia J, Klimstra DS. Pancreatic acinar cell carcinomas with prominent ductal differentiation: mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma. Am J Surg Pathol. 2010;34:510–8.CrossRefGoogle Scholar
  10. 10.
    Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO classification of tumours of the digestive system. Lyon: IARC Press; 2010. p. 314–30.Google Scholar
  11. 11.
    Glazer ES, Neill KG, Frakes JM, Coppola D, Hodul PJ, Hoffe SE, et al. Systematic review and case series report of acinar cell carcinoma of the pancreas. Cancer Control. 2016;23(4):446–54.CrossRefGoogle Scholar
  12. 12.
    Kruger S, Haas M, PJ BB, Ormanns S, Modest DP, Westphalen CB, et al. Acinar cell carcinoma of the pancreas: a rare disease with different diagnostic and therapeutic implications than ductal adenocarcinoma. J Cancer Res Clin Oncol. 2016;142(12):2585–91.CrossRefGoogle Scholar
  13. 13.
    Distler M, Rückert F, Dittert DD, Stroszczynski C, Dobrowolski F, Kersting S, et al. Curative resection of a primarily unresectable acinar cell carcinoma of the pancreas after chemotherapy. World J Surg Oncol. 2009;7:22.CrossRefGoogle Scholar
  14. 14.
    Klimstra DS, Heffess CS, Oertel JE, Rosai J. Acinar cell carcinoma of the pancreas: a clinicopathological study of 28 cases. Am J Surg Pathol. 1992;16:815–37.CrossRefGoogle Scholar
  15. 15.
    Butturini G, Pisano M, Scarpa A, et al. Aggressive approach to acinar cell carcinoma of the pancreas: a single-institution experience and a literature review. Langenbeck's Arch Surg. 2011;396:363–9.CrossRefGoogle Scholar
  16. 16.
    Schmidt CM, Matos JM, Bentrem DJ, Talamonti MS, Lillemoe KD, Bilimoria KY. Acinar cell carcinoma of the pancreas in the United States: prognostic factors and comparison to ductal adenocarcinoma. J Gastrointest Surg. 2008;12:2078–86.CrossRefGoogle Scholar
  17. 17.
    Cananzi FCM, Jayanth A, Lorenzi B, Belgaumkar A, Mochlinski K, Sharma A, et al. ‘Chronic’ metastatic pancreatic acinar cell carcinoma. Pancreatology. 2013;13:549–52.CrossRefGoogle Scholar
  18. 18.
    Armstrong MD, Von Hoff D, Barber B, Marlow LA, von Roemeling C, Cooper SJ, et al. An effective personalized approach to a rare tumor: prolonged survival in metastatic pancreatic acinar cell carcinoma based on genetic analysis and cell line development. J Cancer. 2011;2:142–52.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Hemanth Makineni
    • 1
  • Ramakrishnan Ayloor Seshadri
    • 1
    Email author
  • Shirley Sundersingh
    • 2
  1. 1.Department of Surgical OncologyCancer Institute (WIA)ChennaiIndia
  2. 2.Department of OncopathologyCancer Institute (WIA)ChennaiIndia

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