Diffuse, Aggressive Metastatic Progression after Minimally Invasive Local Resection of Primary Gastric Synovial Sarcoma: a Case Report and Systematic Review of the Literature
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Synovial sarcoma is a malignant mesenchymal neoplasm accounting for about 5 to 10% of all soft tissue sarcomas. It occurs predominantly in young adults (15–40 years) with a slight male preponderance (male/female 1.2:1) [1, 2]. Synovial sarcoma was historically thought to originate from synovial lining, but later studies have found that synovial differentiation is lacking , and cell lineage remains unknown. Approximately 90% of synovial sarcomas occur in the extremities, and fewer than 5% occur in a joint or bursa. Rarely, they have been reported in other sites, including head and neck, thoracic wall and cavity, abdomen and pelvis, male and female genitourinary tracts, gastrointestinal tract, bone, and nervous system [1, 2].
Synovial sarcoma of the stomach is extremely rare with only less than 30 cases reported in the literature. The diagnosis of this spindle cell tumor hinges on identification of the t(X;18)(p11.2;q11.2) translocation, which results in SS18-SSX1, SS18-SSX2...
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The authors declare that they have no conflict of interest.
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