Advertisement

Journal of Gastrointestinal Cancer

, Volume 50, Issue 1, pp 116–122 | Cite as

Diffuse, Aggressive Metastatic Progression after Minimally Invasive Local Resection of Primary Gastric Synovial Sarcoma: a Case Report and Systematic Review of the Literature

  • Shaomin Hu
  • Kristen Wong
  • K. H. Ramesh
  • Esperanza Villanueva-Siles
  • Nicole Panarelli
  • Haejin InEmail author
Case Report
  • 56 Downloads

Introduction

Synovial sarcoma is a malignant mesenchymal neoplasm accounting for about 5 to 10% of all soft tissue sarcomas. It occurs predominantly in young adults (15–40 years) with a slight male preponderance (male/female 1.2:1) [1, 2]. Synovial sarcoma was historically thought to originate from synovial lining, but later studies have found that synovial differentiation is lacking [2], and cell lineage remains unknown. Approximately 90% of synovial sarcomas occur in the extremities, and fewer than 5% occur in a joint or bursa. Rarely, they have been reported in other sites, including head and neck, thoracic wall and cavity, abdomen and pelvis, male and female genitourinary tracts, gastrointestinal tract, bone, and nervous system [1, 2].

Synovial sarcoma of the stomach is extremely rare with only less than 30 cases reported in the literature. The diagnosis of this spindle cell tumor hinges on identification of the t(X;18)(p11.2;q11.2) translocation, which results in SS18-SSX1, SS18-SSX2...

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Thway K, Fisher C. Synovial sarcoma: defining features and diagnostic evolution. Ann Diagn Pathol. 2014;18:369–80.CrossRefGoogle Scholar
  2. 2.
    Fisher C. Synovial sarcoma. Ann Diagn Pathol. 1998;2:401–21.CrossRefGoogle Scholar
  3. 3.
    Billings SD, Meisner LF, Cummings OW, et al. Synovial sarcoma of the upper digestive tract: a report of two cases with demonstration of the X;18 translocation by fluorescence in situ hybridization. Mod Pathol. 2000;13:68–76.CrossRefGoogle Scholar
  4. 4.
    Akhunji S, Musil I, Baisre de Leon A, et al. Synovial sarcoma arising in the gastric wall. Cancer Ther. 2007;5:457–62.Google Scholar
  5. 5.
    Makhlouf HR, Ahrens W, Agarwal B, et al. Synovial sarcoma of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 10 cases. Am J Surg Pathol. 2008;32:275–81.CrossRefGoogle Scholar
  6. 6.
    Sinniah RP, Roche E, Cameron D. GI synovial sarcomas. Clin Transl Gastroenterol. 2012;3:e11.CrossRefGoogle Scholar
  7. 7.
    Wang CC, Wu MC, Lin MT, et al. Primary gastric synovial sarcoma. J Formos Med Assoc. 2012;111:516–20.CrossRefGoogle Scholar
  8. 8.
    Kamata K, Wada R, Yajima N, et al. Primary gastric synovial sarcoma: molecular diagnosis and prediction of prognosis. Clin J Gastroenterol. 2013;6:303–8.CrossRefGoogle Scholar
  9. 9.
    Sahara S, Otsuki Y, Egawa Y, et al. Primary synovial sarcoma of the stomach--a case report and review of the literature. Pathol Res Pract. 2013;209:745–50.CrossRefGoogle Scholar
  10. 10.
    Michot N, Robert PE, De Muret A, et al. Gastric synovial sarcoma: case report and systematic review of literature. J Gastrointest Cancer. 2014;45(Suppl 1):129–31.CrossRefGoogle Scholar
  11. 11.
    Torres Rivas HE, Fernandez S, Fresno MF. Primary gastric synovial sarcoma. Pathology. 2014;46:253–6.CrossRefGoogle Scholar
  12. 12.
    Wong NA, Campbell F, Shepherd NA. Abdominal monophasic synovial sarcoma is a morphological and immunohistochemical mimic of gastrointestinal stromal tumour. Histopathology. 2015;66:974–81.CrossRefGoogle Scholar
  13. 13.
    Romeo S, Rossi S, Acosta Marin M, et al. Primary synovial sarcoma (SS) of the digestive system: a molecular and clinicopathological study of fifteen cases. Clin Sarcoma Res. 2015;5:7.CrossRefGoogle Scholar
  14. 14.
    Hemmings C, Yip D. The changing face of GIST: implications for pathologists. Pathology. 2014;46:141–8.CrossRefGoogle Scholar
  15. 15.
    Medeiros F, Corless CL, Duensing A, et al. KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications. Am J Surg Pathol. 2004;28:889–94.CrossRefGoogle Scholar
  16. 16.
    Yamamoto H, Handa M, Tobo T, et al. Clinicopathological features of primary leiomyosarcoma of the gastrointestinal tract following recognition of gastrointestinal stromal tumours. Histopathology. 2013;63:194–207.CrossRefGoogle Scholar
  17. 17.
    Cirocchi R, Trastulli S, Desiderio J, et al. Gastric carcinosarcoma: a case report and review of the literature. Oncol Lett. 2012;4:53–7.CrossRefGoogle Scholar
  18. 18.
    Fong Y, Coit DG, Woodruff JM, et al. Lymph node metastasis from soft tissue sarcoma in adults. Analysis of data from a prospective database of 1772 sarcoma patients. Ann Surg. 1993;217:72–7.CrossRefGoogle Scholar
  19. 19.
    Sherman KL, Kinnier CV, Farina DA, et al. Examination of national lymph node evaluation practices for adult extremity soft tissue sarcoma. J Surg Oncol. 2014;110:682–8.CrossRefGoogle Scholar
  20. 20.
    Salah S, Yaser S, Salem A, et al. Factors influencing survival in metastatic synovial sarcoma: importance of patterns of metastases and the first-line chemotherapy regimen. Med Oncol. 2013;30:639.CrossRefGoogle Scholar
  21. 21.
    Gong N, Wong CS, Chu YC. Is lymph node metastasis a common feature of gastrointestinal stromal tumor? PET/CT correlation. Clin Nucl Med. 2011;36:678–82.CrossRefGoogle Scholar
  22. 22.
    Kodera Y, Fujiwara M, Ohashi N, et al. Laparoscopic surgery for gastric cancer: a collective review with meta-analysis of randomized trials. J Am Coll Surg. 2010;211:677–86.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Shaomin Hu
    • 1
  • Kristen Wong
    • 2
  • K. H. Ramesh
    • 1
  • Esperanza Villanueva-Siles
    • 1
  • Nicole Panarelli
    • 1
  • Haejin In
    • 2
    Email author
  1. 1.Department of Pathology, Montefiore Medical CenterAlbert Einstein College of MedicineBronxUSA
  2. 2.Department of Surgery, Montefiore Medical CenterAlbert Einstein College of MedicineBronxUSA

Personalised recommendations