Journal of Gastrointestinal Cancer

, Volume 48, Issue 3, pp 262–266 | Cite as

Validation of a Liver Index and Its Significance for HCC Aggressiveness

  • Brian I. CarrEmail author
  • Vito Guerra
Original Research



We recently constructed a liver index (LI) from four liver parameters, namely: blood total bilirubin, gamma glutamyl transpeptidase (GGTP), albumin, and platelet levels (a cirrhosis surrogate). We found that the scores for the liver index related significantly to a four-parameter HCC aggressiveness index (maximum tumor diameter, multifocality, percent portal vein invasion, and blood AFP levels).


To validate the relationship of liver parameters to tumor aggressiveness parameters in a larger, different HCC dataset.


We now confirm these associations in another large HCC cohort. Furthermore, this liver index showed significant trends with the individual HCC aggressiveness parameters.


These results provide further support for the idea that liver microenvironment, as reflected in liver function tests, may relate to HCC behavior.


HCC parameters Aggressiveness index Liver function 



Hepatocellular carcinoma




Gamma glutamyl transpeptidase


Portal vein thrombosis


Maximum tumor diameter


Computerized axial tomography scan









No authors have any proprietary or financial interests.

Compliance with Ethical Standards



Grant Support



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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Izmir Biomedicine and Genome CenterDokuz Eylul UniversityIzmirTurkey
  2. 2.Department of Clinical TrialsIRCCS de BellisCastellana GrotteItaly

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