Journal of Gastrointestinal Cancer

, Volume 48, Issue 3, pp 274–275 | Cite as

Hepatocellular Cancer: Is Recurrence Inevitable?

  • Levent DoganayEmail author
Review Article


Hepatocellular cancer (HCC) ranks as the sixth common cancer in the world [1]. Yearly, it is estimated that more than 700,000 people are diagnosed with HCC. However, when it comes to mortality, it is the second cause [1, 2]. More than half of the HCC patients are from East Asia and the most prevalent liver disease causing HCC is chronic hepatitis B (HBV) infection there. The other underlying disorders are chronic hepatitis C infection, alcohol abuse, and metabolic syndrome. Tobacco smoking and dietary aflatoxin exposure are additional confounding factors [3].

Despite advances in medicine, recurrence after HCC treatment are unacceptably high. In the long-term recurrence, free survival is less than 40% after loco-regional treatments [4]. Here, the current literature in recurrence of HCC is reviewed.

Curative Strategies in HCC Treatment and Recurrence

HCC treatment algorithm is not built on a TNM staging system. Barcelona Clinic Liver Cancer (BCLC) staging system in wide use,...


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Department of Gastroenterology and HepatologyUmraniye Teaching and Research HospitalIstanbulTurkey
  2. 2.Gastroenteroloji KlinigiUmraniye Egitim ve Arastirma HastanesiIstanbulTurkey

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