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Immunologic Research

, Volume 67, Issue 1, pp 21–38 | Cite as

Potential roles of neutrophils in maintaining the health and productivity of dairy cows during various physiological and physiopathological conditions: a review

  • Mohanned Naif AlhussienEmail author
  • Ajay Kumar Dang
Review
  • 115 Downloads

Abstract

Neutrophils represent the first line of innate immunity and are the most prominent line of cellular defence against invading microorganisms. On stimulation, they can quickly move through the walls of veins and into the tissues of the body to immediately attack or monitor the foreign antigens. Neutrophils are highly versatile and sophisticated cells which are endowed with highly sensitive receptor-based perception systems. They were traditionally classified as short-lived phagocytes actively involved during infection and inflammation, but recently, it has been seen that neutrophils are capable of detecting the presence of sperms during insemination as well as an implanting embryo in the female reproductive tract. These specialised phagocytes play a major role in tissue remodelling and wound healing, and maintain homeostasis during parturition, expulsion of placenta, folliculogenesis, corpus luteum formation and luteolysis. Here, we review the role played by neutrophils in maintaining homeostasis during normal and inflammatory conditions of dairy cattle. We have summarised the alteration in the expression of some cell adhesion molecules and cytokines on bovine neutrophils during different physiological and physiopathological conditions. Some emerging issues in the field of neutrophil biology and the possible strategies to strengthen their activity during the period of immunosuppression have also been discussed.

Keywords

Neutrophil activity Expression Tissue remodelling Homeostasis Inflammatory disease 

Abbreviations

AI

Artificial insemination

BLAD

Bovine leukocyte adhesion deficiency

BOECs

Bovine oviduct epithelial cells

CL

Corpus luteum

E. coli

Escherichia coli

ECM

Extracellular matrix

FRT

Female reproductive tract

GRα

Glucocorticoid receptor

ICAM-1

Intercellular adhesion molecule-1

IFNT

Interferon-tau

IL

Interleukin

ISG15

Interferon-stimulated gene 15

LPS

Lipopolysaccharide

MHC

Major histocompatibility complex

MMP

Matrix metalloproteinase

MRP

Maternal recognition of pregnancy

NET

Neutrophil extracellular trap

PECAM-1

Platelet/endothelial cell adhesion molecule-1

PGE2

Prostaglandin E2

PGF2α

Prostaglandin F2α

PMN

Polymorphonuclear neutrophils

ROS

Reactive oxygen species

S. aureus

Staphylococcus aureus

SC

Somatic cell

Strep. agalactiae

Streptococcus agalactiae

T. pyogenes

Trueperella pyogenes

TAN

Tumour-associated neutrophil

TGF

Transforming growth factor

TLR

Toll-like receptor

TNF

Tumour necrosis factor

ECs

Endothelial cells

Notes

Acknowledgements

The authors are thankful to the Department of Biotechnology, Ministry of Science and Technology, Government of India for providing financial support and sanctioning various projects on neutrophils. The first author is also thankful to the Syrian University of Aleppo for granting a study leave to carry out his PhD research work.

Funding information

This work was supported by the Department of Biotechnology (Grant Number: BT/PR13016/AAQ/1/4/11/2009; DATED: 22/06/2010, BT/PR8404/AAQ/1/548/2013; DATED: 20/06/2014 and BT/PR23570/AAQ/1/691/2017; Dated: 10/05/2018), Ministry of Science and Technology, Government of India.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Animal Production Division, Agricultural CollegeAleppo UniversityAleppoSyrian Arab Republic
  2. 2.Lactation and Immuno-Physiology LaboratoryICAR-National Dairy Research InstituteKarnalIndia

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